LA JOLLA—Aging involves complicated plot twists and a large cast of characters: inflammation, stress, metabolism changes, and many others. Now, a team of Salk Institute and UC San Diego scientists reveal another factor implicated in the aging process—a class of lipids called SGDGs (3-sulfogalactosyl diacylglycerols) that decline in the brain with age and may have...
Month: <span>November 2022</span>
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FDA OKs Teclistamab for Relapsed/Refractory Multiple Myeloma
M. Alexander Otto, PA, MMS October 25, 2022 The US Food and Drug Administration (FDA) has granted accelerated approval to teclistamab (Tecvayli, Janssen Biotech, Inc.) for adults with relapsed or refractory multiple myeloma after at least four prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody. The results made the...
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New onset chronic kidney disease in people with diabetes highest among ethnic, racial minorities
UNIVERSITY OF CALIFORNIA – LOS ANGELES HEALTH SCIENCES New onset chronic kidney disease (CKD) in people with diabetes is highest among racial and ethnic minority groups compared with white persons, a UCLA-Providence study finds. The study, published as a letter to the editor in the New England Journal of Medicine, found that new onset CKD rates...
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A new paradigm to enhance tumour targeting with biomimetic nanovectors
UNIVERSITY OF EASTERN FINLAND A new technique to improve the coating of nanoparticles used in cancer therapy may enhance tumour targeting, a new study carried out in collaboration between the University of Eastern Finland and Anhui Medical University in China concludes. Tumour targeting is a prerequisite for effective cancer therapy because it enhances the therapeutic...
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Reprogramming of immune cells shown to fight off melanoma
UNIVERSITY OF BRISTOL IMAGE: ILLUSTRATION SHOWING HOW MINIATURE ARTIFICIAL PROTOCELLS LOADED WITH ANTI-MICRORNA-223 CARGO CAN REPROGRAM CANCER-ASSOCIATED MACROPHAGES IN LARVAL AND ADULT ZEBRAFISH LEADING THEM TO BE MORE PRO-INFLAMMATORY AND THUS ABLE TO DRIVE MELANOMA SHRINKAGE CREDIT: PACO LOPEZ CUEVAS A new way of reprogramming our immune cells to shrink or kill off cancer cells...
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Stealth-care system: Scientists test ‘smart’ red blood cells to deliver antibiotics that target specific bacteria
MCMASTER UNIVERSITY IMAGE: SCIENTISTS TEST ‘SMART’ RED BLOOD CELLS TO DELIVER ANTIBIOTICS THAT TARGET SPECIFIC BACTERIA CREDIT: ELLA MARUSHCHENKO Physicists at McMaster University have identified a natural delivery system which can safely carry potent antibiotics throughout the body to selectively attack and kill bacteria by using red blood cells as a vehicle. The platform, described...
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Study identifies potential new treatment target for sleep apnea
JOHNS HOPKINS MEDICINE In a new study with obese mice, Johns Hopkins Medicine researchers say they have added to evidence that specialized channel proteins are possible therapeutic targets for sleep apnea and similar abnormally slow breathing disorders in obese people. The protein, a cation channel known as TRPM7, is found in carotid bodies, tiny sensory...
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Efficient nanovaccine delivery system boosts cellular immunity
OSAKA METROPOLITAN UNIVERSITY IMAGE: CATIONIC LIPID-INTRODUCED PH-RESPONSIVE POLYSACCHARIDE-MODIFIED LIPOSOMES TO ACHIEVE EFFICIENT ANTIGEN DELIVERY AND HIGHLY ACTIVATION OF ANTIGEN PRESENTING CELLS TOWARDS INDUCTION OF ANTIGEN-SPECIFIC IMMUNE RESPONSES. CREDIT: EIJI YUBA, OSAKA METROPOLITAN UNIVERSITY Cancer immunotherapies, such as immune checkpoint inhibition therapy, have been attracting attention in recent years as new methods for treating cancer. However,...
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AI helps researchers design microneedle patches that restore hair in balding mice
AMERICAN CHEMICAL SOCIETY IMAGE: HAIR REGREW THICKER IN MICE TREATED WITH A MANGANESE-NANOZYME MICRONEEDLE PATCH (RIGHT-SIDE IMAGE, LABELED MNMNP) COMPARED TO THOSE TREATED WITH TESTOSTERONE AS A CONTROL (LEFT-SIDE IMAGE). CREDIT: ADAPTED FROM NANO LETTERS 2022, DOI: 10.1021/ACS.NANOLETT.2C03119 Hair loss is undesirable for many men — and women — because one’s hairstyle is often closely...
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Transistors help identify cancer cell markers
TOKYO MEDICAL AND DENTAL UNIVERSITY IMAGE: ION-SENSITIVE FIELD EFFECT TRANSISTORS DETECT BREAST CANCER CELLS EXPRESSING EGFR WHEN BOUND BY AN ANTIBODY LINKED TO A CHEMICAL REPORTER CREDIT: DEPARTMENT OF BIOELECTRONICS, TMDU Researchers from Tokyo Medical and Dental University (TMDU) find that ion-sensitive field effect transistors can be combined with enzymatic chemical signal amplification to detect...