by University of Cambridge Credit: CC0 Public Domain Cambridge researchers have developed a method for measuring overall fitness accurately on wearable devices—and more robustly than current consumer smartwatches and fitness monitors—without the wearer needing to exercise. Normally, tests to accurately measure VO2max—a key measurement of overall fitness and an important predictor of heart disease and mortality risk—require...
mRNA vaccines offer one-two punch to combat malaria
by George Washington University Credit: CC0 Public Domain Malaria is found in more than 90 countries around the world, causing 241 million cases and an estimated 627,000 deaths every year. Vaccines are one intervention that could help eliminate this deadly disease, yet a highly effective vaccine remains elusive. Recent technological advances in vaccine development–such as...
Advances in detection of erratic heart rhythm
by CORDIS Credit: Tasha Horse/Shutterstock.com New research supported by the euCanSHare and HealthyCloud projects has revealed that a model combining ECG features and cardiac imaging-derived radiomics data improves the detection of AF in women. The study was published in the journal Scientific Reports. AF is a heart condition characterized by an irregular and often abnormally fast...
Swelling along brain’s axons may be true culprit in Alzheimer’s disease
by Bill Hathaway, Yale University Reduction in axonal spheroids by Pld3 deletion improves neural circuit function. a, Schematics of cholinergic neurons in the basal forebrain projecting to the cortex, infected with AAV viruses encoding either Pld3 or control sgRNAs (left). Right, two-photon images showing intermingled projecting basal forebrain axons (red) from the basal forebrain (red)...
New study puts gut microbiome at the center of Parkinson’s disease pathogenesis
by Bob Shepard, University of Alabama at Birmingham The study, utilizing the relatively new field of metagenomics, demonstrated an imbalance in the gut microbiome of patients with Parkinson’s disease. Credit: University of Alabama at Birmingham New research from the University of Alabama at Birmingham says the gut microbiome is involved in multiple pathways in the...
How gravity may cause irritable bowel syndrome
by Cedars-Sinai Medical Center Credit: CC0 Public Domain A new theory suggests irritable bowel syndrome (IBS), the most common gastrointestinal disorder, may be caused by gravity. Brennan Spiegel, MD, MSHS, director of Health Services Research at Cedars-Sinai and author of the hypothesis, explains that IBS—and many other conditions—could result from the body’s inability to manage gravity....
Squamous cell carcinoma study: Cancer stem cells are fueled through dialogue with their environments
by Rockefeller University TGF beta signaling (red) is one way that the environment causes cancer stem cells at the stroma-tumor border (green) to become invasive. Living cells are dyed blue. Credit: Shaopeng Yuan What drives tumor growth? Is it a few rogue cells imposing their will upon healthy tissue, or diseased tissue bringing out the...
Deteriorating neurons are source of human brain inflammation in Alzheimer’s disease
by Salk Institute Neurons (green) derived from a patient with Alzheimer’s disease. The nuclei (blue) of the neurons are also shown. Credit: Salk Institute Despite decades of research, Alzheimer’s disease remains a debilitating and eventually fatal dementia with no effective treatment options. More than 95 percent of Alzheimer’s disease cases have no known origin. Now,...
New potential mechanism for vision loss discovered
by Dresden University of Technology Microscopic images of lab-grown mini-retinas, so called human retina organoids. The left image shows a section of a healthy (control) organoid, whereas the right image shows an organoid section with pathological changes. On the right, there is a massive loss of photoreceptor neurons that are labeled in green. The red...
COVID-19 patients show liver injury months after infection
by Radiological Society of North America Credit: CC0 Public Domain COVID-19 infection is associated with increased liver stiffness, a sign of possible long-term liver injury, according to the results of a new study being presented today at the annual meeting of the Radiological Society of North America (RSNA). “Our study is part of emerging evidence...