by Oregon State University Dynein intermediate chain structure showing folded WD repeat domain in the center (blue) and disordered N-terminal domain (orange). Illustrated on the left are multiple models of open and closed structures of the disordered domain (grey) bound to light chains (yellow, red and orange blobs). Image provided by Elisar Barbar, OSU College...
by Insilico Medicine Schematic representation of the PandaOmics application for a rapid biomarker discovery and target characterization in cancer. Gene expression signatures have been examined in DNA repair diseases with high cancer predisposition (1), followed by the analysis of the most significantly perturbed genes as potential biomarkers stratifying cancer patients based on their survival rates...
by Max Planck Society Rapamycin prolongs lifespan only in female fruit flies. Credit: K. Link/Max Planck Institute for Biology of Ageing The effect of medicines on women and men can differ significantly. This also applies to the currently most promising anti-aging drug rapamycin, as researchers from the Max Planck Institute for Biology of Ageing in...
Written by Stacia Woodcock, PharmD | Reviewed by Alyssa Billingsley, PharmDUpdated on October 28, 2022 Key takeaways: If you’re feeling fatigued, it’s possible your medication is the cause. For example, medications like fluoxetine (Prozac) and propranolol (Inderal) can make you feel tired. In some cases, drowsiness will go away over time as your body adjusts to the...
by Forsyth Institute Credit: CC0 Public Domain As any weekend warrior understands, cartilage injuries to joints such as knees, shoulders, and hips can prove extremely painful and debilitating. In addition, conditions that cause cartilage degeneration, like arthritis and temporomandibular joint disorder (TMJ), affect 350 million people in the world and cost the U.S. public health system...
by KU Leuven A histologic section of a mouse bone fracture. Safranin O has been used to colour the cartilage cells red (specifically the proteins produced by cartilage cells); all other tissues are blue. Credit: Nick van Gastel. In the event of a bone fracture, fatty acids in the blood signal to stem cells that...
By STEPHANIE DUTCHEN November 28, 2022 Research Cryo-EM revealed the inflammasome from different angles. Images: Wu lab Researchers in the lab of Harvard Medical School structural biologist Hao Wu have deciphered the step-by-step assembly of a molecular complex that’s crucial for fighting off infections but can also give rise to myriad diseases involving inflammation, from gout to Alzheimer’s to...
by Indiana University School of Medicine Pharmacokinetic analysis of levetiracetam (LEV) in 6-month aged 5XFAD mice reveals significant sex differences. A, Plasma concentration time profiles of LEV by dose and sex in 5XFAD males and females. B, One-compartment model fit for the 30 mg/kg dose. C, Volume of distribution (V/F) and clearance (CL/F) is shown....
by University of California, Irvine Selective cilia deletion in the striatum and confirmation of mice’s normal gross growth and well-being. a Schematic view of experimental design and behavior assays performed and their sequence. Diagram was created with the BioRender.com webpage. b Schematic showing bilateral viral injection into the dorsal striatum. c and d Verification of...
by American Academy of Neurology Credit: Pixabay/CC0 Public Domain A number of new neurologic medications for diseases like multiple sclerosis (MS), Parkinson’s disease and migraine have received U.S. Food and Drug Administration (FDA) approval over the past decade. However, with most having higher out-of-pocket costs and benefits similar to existing, less expensive drugs, only a...
