Year: <span>2022</span>

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Study finds hepatitis C treatment gap for individuals with alcohol use disorder
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Study finds hepatitis C treatment gap for individuals with alcohol use disorder

by NIH/National Institute on Alcohol Abuse and Alcoholism  Credit: Unsplash/CC0 Public Domain A new study supported by the National Institutes of Health shows that individuals with alcohol use disorder (AUD) are less likely to receive antivirals for hepatitis C, despite current guidelines recommending antiviral treatment regardless of alcohol use. Direct-acting antiviral treatment is highly effective...

In preclinical studies, team identifies potential therapy for metastatic colon cancer
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In preclinical studies, team identifies potential therapy for metastatic colon cancer

by Weill Cornell Medical College Multiplex immunofluorescence image of hyaluronan-rich human colorectal cancer. Highly aggressive tumoral cells (turquoise and magenta) are negative for both aPKCs (yellow). The hyaluronan deposition in the stroma is labeled in green, and nuclei in blue. Credit: Moscat and Diaz-Meco labs. An experimental therapy has shown promise in preclinical models as...

Florida International University researchers patent synthetic antibiotic
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Florida International University researchers patent synthetic antibiotic

FLORIDA INTERNATIONAL UNIVERSITY COLLEGE OF MEDICINE IMAGE: MASAFUMI YOSHINAGA, PH.D., BARRY P. ROSEN, PH.D., STANISLAW WNUK, PH.D., AND THE CHEMICAL FORMULA FOR ARSINOTHRICIN. CREDIT: FLORIDA INTERNATIONAL UNIVERSITY Florida International University researchers have moved a step closer to producing synthetic arsenic-based drugs in their quest to solve an urgent worldwide health problem ―the growing number of...

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Bioengineered synthetic gene circuits enhance cancer immunotherapies

AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE (AAAS) In two separate studies, researchers demonstrate how synthetic biology can be used to tackle a difficult issue in cancer immunotherapy: the way immunotherapy-related approaches focused on short-term killing of tumor cells may fail to eradicate tumors because growth of tumors happens on longer timescales. Here, two research groups...

Starvation causes cell remodelling
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Starvation causes cell remodelling

LEIBNIZ-FORSCHUNGSINSTITUT FÜR MOLEKULARE PHARMAKOLOGIE IMAGE: IN FED CELLS, EARLY ENDOSOMES FORM CONTACTS WITH ER TUBULES. TUBULAR ER MEMBRANES FACILITATE MITOCHONDRIAL FISSION AND SERVE AS SOURCE FOR LIPID DROPLET FORMATION. NUTRIENT STARVATION-INDUCED HYDROLYSIS OF ENDOSOMAL PI(3)P BY MTM1 REDUCES MEMBRANE CONTACTS BETWEEN THE TUBULAR ER AND EARLY ENDOSOMES. THE RESULTING LOSS OF PERIPHERAL ER TUBULES INDUCES...

Pandemic’s many effects on older women documented
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Pandemic’s many effects on older women documented

by The Gerontological Society of America  Concern regarding the COVID-19 pandemic among Women’s Health Initiative (WHI) participants from March 2020 to October 2020. The mode survey response reported by WHI participants residing in each ZIP code is shown. COVID-19 = coronavirus disease 2019. Credit: The Journals of Gerontology: Series A (2022). DOI: 10.1093/gerona/glac056 A new supplemental issue...

Looking for an early sign of LATE: New insights into the pathology
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Looking for an early sign of LATE: New insights into the pathology

by University of California – San Diego Fluorescent activated cell sorting (FACS) enrichment of plasma NDEVs, ADEVs, and MDEVs from LATE-NC subjects. Representative FACS plot for non-EV, negative control (red) and BAE—FITC complexes generated from EVs (green) isolated a LATE-NC subject and enriched against anti-human CD171 biotin (L1-CAM), anti-GLAST, and anti-TMEM119 antibody. (A) Representative plot...

Revised normative blood pressure values for children show better discrimination of kidney disease risk
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Revised normative blood pressure values for children show better discrimination of kidney disease risk

by National Kidney Foundation  Credit: Pixabay/CC0 Public Domain Analysis recently published in the American Journal of Kidney Diseases (AJKD) compared and contrasted the 2017 and 2004 American Academy of Pediatrics (AAP) childhood hypertension guidelines and showed higher levels of proteinuria in children with hypertensive range blood pressure (BP) with 2017 vs. 2004 blood pressure percentiles. This comparison...

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Picking out a Ukrainian Brides Fraud

The internet is usually rife with webpages advertising women who need to leave their particular country of origin and find a fresh life in foreign countries. While this could be a fantastic way to find a spouse, it is not without its hazards. Scam artists employ emotional leads to to capture interest and adjust visitors...

Oral contraceptives affect women’s health; age and gut microbiome may play a role
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Oral contraceptives affect women’s health; age and gut microbiome may play a role

by University of Ottawa Credit: CC0 Public Domain The effects of oral contraceptives (OCs) like birth control pills on the brain and mood of women may come down to age and their gut microbiome, according to new research from the University of Ottawa. In a manuscript published in January’s Frontiers in Neuroendocrinology, a team from the...