REGENSTRIEF INSTITUTE One of the first real-world data studies comparing the new bivalent mRNA COVID-19 booster vaccines with the original monovalent vaccines reports the bivalent conveyed greater short-term protection against symptomatic COVID-19 infection in adults. The multi-state study from the Centers for Disease Control and Prevention’s VISION Network found that the bivalent booster dose provides greater...
Year: <span>2022</span>
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HPV vaccination rates increased after ACIP update for adults aged 27 to 45
by Elana Gotkine HealthDay Reporter Increases in human papillomavirus (HPV) vaccine administration were seen in adults aged 27 to 45 years after the Advisory Committee on Immunization Practices (ACIP) recommended patient-clinician shared decision-making about HPV vaccination in adults aged 27 to 45 years in 2019, according to a study published online Dec. 16 in JAMA Health...
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Why do many young cancer survivors forgo human papillomavirus vaccination?
by Wiley TEM of papillomavirus. Credit: Public Domain Although young cancer survivors face an elevated risk for later developing cervical, oropharyngeal, and several other human papillomavirus (HPV)–related cancers, HPV vaccination rates among this group remain low. This is primarily because of certain vaccine‐related concerns, according to a study published by Wiley online in Cancer, a peer-reviewed...
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Metformin use significantly reduces risk of joint replacement in people with type 2 diabetes
by Canadian Medical Association Journal Credit: CC0 Public Domain Osteoarthritis is a common chronic condition that usually causes joint pain and can be severe enough to require knee and hip replacements. In the United States, the number of total knee replacement (TKR) and total hip replacement (THR) surgeries is estimated to reach 572 000 per...
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Microbiome: Scientists highlight role of harmful gut bacteria in fever afflicting cancer patients
by Delthia Ricks, Medical Xpress Schematic of histological quantification of the dense inner colonic mucus layer histologically, following PAS staining. Eight equally radially spaced sites are identified for mucus layer thickness quantification which are then averaged for each sample. Credit: Science Translational Medicine (2022). DOI: 10.1126/scitranslmed.abo3445 An altered gut microbiome is an unexpected cause of fever afflicting...
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New aptamer drug for bone anabolic therapies
by Hong Kong Baptist University Graphical abstract. Credit: Theranostics (2022). DOI: 10.7150/thno.63177 A research team led by Hong Kong Baptist University (HKBU) has identified a molecular target for bone anabolic therapies using a selected aptamer that serves as an inhibitor of sclerostin, a protein that prevents bone growth. The discovery offers hope for the development of an...
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Metformin relies on the action of a cellular-stress-response protein, study finds
by University of Barcelona The study identifies the cytokine GDF15, a protein whose expression increases in response to cellular stress, as a key factor for the metformin drug to show antidiabetic effects. Credit: Pharmacological Research (2022). DOI: 10.1016/j.phrs.2022.106578 Metformin, the most prescribed drug for treating diabetes mellitus, known as type 2 diabetes, requires the presence of the...
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Researchers expanding the types of cancer CAR-T therapy can target
by Gregory Allen, The Conversation Killer T cells (green and red), or cytotoxic T cells, surround a cancer cell (blue, center). Credit: NICHD/J. Lippincott-Schwartz, CC BY-NC-ND Teaching the body’s immune cells to recognize and fight cancer is one of the holy grails in medicine. Over the past two decades, researchers have developed new immunotherapy drugs that stimulate...
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Wearable skin patch monitors hemoglobin in deep tissues
by Emerson Dameron, University of California – San Diego A photoacoustic sensor capable of monitoring hemoglobin deep below the skin could help clinicians diagnose tumors, organ malfunctions and more. Credit: Xiaoxiang Gao for the Jacobs School of Engineering at UC San Diego A team of engineers at the University of California San Diego has developed...
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Rheumatoid arthritis linked to peripheral artery disease
by Lori Solomon There may be an association between rheumatoid arthritis (RA) and peripheral artery disease (PAD), according to a review published online Nov. 30 in Rheumatology International. Tayser Zoubi, from Flinders University in Adelaide, Australia, and Hendry Gordon, Ph.D., from Glasgow Caledonian University in the United Kingdom, conducted a systematic literature review to examine the...