by Cleveland Clinic Credit: Journal of Clinical Investigation (2023). DOI: 10.1172/JCI163498 A new prostate cancer therapy in clinical trials could treat patients resistant to treatment through targeting the disease on a molecular level, based on new Cleveland Clinic research. Prostate cancer affects one out of every nine men. Most patients respond to chemical or surgical castration, which stops the body...
Combining multiple maps reveals new genetic risk factors for blindness
by Public Library of Science Composite of an embryonic mouse eye cup (E14.5) labeled with antibodies against the developmental transcription factors Lhx2 (red) and Otx2 (green), and cultured human retinal pigmented epithelium (RPE) labeled with antibodies against MITF (red) and ZO-1 (green). Credit: Mazal Cohen-Gulkar, composite by Ruth Ashery-Padan (CC-BY 4.0, https://creativecommons.org/licenses/by/4.0/) Combining a map of...
Researchers link ovarian cancer to bacteria colonization in microbiome
by Susan Murphy, Mayo Clinic β-diversities measures were compared. For β-diversity, Bray–Curtis (BC), unweighted, and weighted, UniFrac distance metrics were reported. The most significant metric is shown in each ordination plot. (A–D) Bacterial community β-diversity between OC patients with sensitive vs other (resistant/refractory) tumor response. Fallopian tube, (A) β-diversity: sensitive vs other (p = 0.003). Ovaries, (B)...
Researchers identify new therapeutic approach to prevent ARDS
by University of California, Irvine Credit: iScience (2022). DOI: 10.1016/j.isci.2022.105901 A novel peptide designed by University of California, Irvine researchers has been found to suppress the damaging lung inflammation seen in acute respiratory distress syndrome, or ARDS. The study, which appears in iScience, describes the first specific treatment designed to prevent the deadly disease, which can appear in patients with...
Study explores effects of dietary choline deficiency on neurologic and system-wide health
by Arizona State University Choline is a vital nutrient for brain and body health. While it is available in a variety of foods, most Americans do not meet the required amount for proper health. A new study suggests that insufficient choline can lead to pathologies in the heart and liver and is associated with the...
One-minute exposure to monochromatic light shown to modify neural connections
by Universitat Politècnica de Catalunya Images showing the results of the tests that made it possible to observe the changes in brain connectivity. Credit: Universitat Politècnica de Catalunya A study led by researchers from the UPC’s Terrassa School of Optics and Optometry (FOOT) shows that 1-minute stimulation with blue, green or red light activates several visual and...
Family dynamics and doctors’ emotions drive useless end-of-life care, says study
by Rutgers University Credit: Unsplash/CC0 Public Domain Researchers from Rutgers and other universities have developed a behavioral model that explains a long-standing health care mystery: Why do so many terminally ill patients undergo intense last-ditch treatments with little chance of meaningful life extension? Surveys repeatedly indicate that nearly all people would rather die peacefully at home,...
World first test to detect diabetics at risk of kidney disease
by Monash University Credit: Pixabay/CC0 Public Domain In a world first international study led by Monash University researchers in Australia, the genetic markers for people with diabetes at risk of developing kidney disease have been identified. The study opens the way for the development of a test that could predict those adults with Type 1 diabetes at...
Nasal delivery of antibodies helps treat symptoms of a stroke in mice
by Bob Yirka, Medical Xpress Credit: Pixabay/CC0 Public Domain A team of researchers affiliated with multiple institutions in Switzerland and Germany has found that antibodies that heal the brain after a stroke can be delivered via nasal spray in mice. Their study was published in Proceedings of the National Academy of Sciences. Ischemic strokes occur when an artery...
Tuberculosis researchers find link between vaccine efficacy, environmental pathogens
by Anne Manning, Colorado State University Graphical abstract. Credit: Cell Reports (2022). DOI: 10.1016/j.celrep.2022.111783 Tuberculosis is an infectious disease of the lungs that’s been with humanity for centuries and affects a quarter of the world’s population. The stubborn disease killed over a million and a half people in 2021, mostly in lower- and middle- income countries where access...