by University of Oxford Diagram illustrating the anti-inflammatory role of all-trans retinoic acid (atRA) after cartilage injury. Credit: Science Translational Medicine (2022). DOI: 10.1126/scitranslmed.abm4054 A new study, published in Science Translational Medicine by researchers at the University of Oxford has identified that Talarozole, a drug that is known to increase retinoic acid, was able to prevent osteoarthritis (OA) in disease models. Tonia...
by Linda Koffmar, The Swedish Research Council Co-expression of fibroblast and adipocyte markers suggest lipomatosis is driven by adipogenic transdifferentiation of medullary fibroblasts. Immunofluorescence staining of lymph nodes (LNs) with lipomatosis. (A) Presence of adipocytes (perilipin, magenta) and fibroblasts (alpha smooth muscle actin; αSMA, green) in medullary cords. Arrowheads indicate adipocytes present in the layer of medullary...
by Arizona State University The illustration shows the cell types and brain regions affected by six different neurodegenerative diseases: Friedreich’s ataxia (purple); Huntington’s disease (blue); frontotemporal dementia (yellow); amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND) or Lou Gehrig’s disease (green); Parkinson’s disease (orange); and Alzheimer’s disease (pink). Credit: Shireen Dooling A perplexing...
by Duke University Medical Center Credit: Unsplash/CC0 Public Domain The reason some people fail to recover their sense of smell after COVID-19 is linked to an ongoing immune assault on olfactory nerve cells and an associated decline in the number of those cells, a team of scientists led by Duke Health report. The finding, publishing online...
by University of California, San Francisco Credit: CC0 Public Domain Ten young children born without functioning immune systems and lacking the ability to fight infections are on track for healthier lives thanks to a new gene therapy treatment pioneered at UC San Francisco, reports a Dec. 22 study in the New England Journal of Medicine. The children...
by UT Southwestern Medical Center These representative hearts from 12-week-old mice show a normal heart (left) and an enlarged heart that’s characteristic of dilated cardiomyopathy. Credit: UT Southwestern Medical Center Using the CRISPR-Cas9 gene editing system, UT Southwestern researchers corrected mutations responsible for a common inherited heart condition called dilated cardiomyopathy (DCM) in human cells and a mouse...
by University of Bonn Blood vessels (red) migrate in a disorganized manner to regions with motor neurons (green). Credit: AG Ruiz de Almodovar/University of Bonn Nerve cells need a lot of energy and oxygen. They receive both through the blood. This is why nerve tissue is usually crisscrossed by a large number of blood vessels. But...
