by Trinity College Dublin Graphical abstract. Credit: Journal of Clinical Investigation (2022). DOI: 10.1172/JCI162581 A review of the COVID-19 vaccine trials indicate that adenovirus vectored vaccines may have non-specific protective effects resulting in significantly reduced all-cause mortality and non-COVID deaths, compared with mRNA based COVID-19 vaccines. The mechanism behind this observation is unknown. New Trinity research has discovered that...
Damian McNamara, MA January 18, 2023 Concerns over drug interactions, existing health conditions and, to a lesser extent, risk of rebound were reasons providers cited in a new Medscape survey examining why healthcare professionals hesitate to prescribe Paxlovid in older adults. The survey also reveals differences in attitudes and prescribing behaviors for Paxlovid (nirmatrelvir/ritonavir) among more than...
by University of Maryland School of Medicine Credit: Unsplash/CC0 Public Domain Patients who have surgery to repair bone fractures typically receive a type of injectable blood thinner, low-molecular-weight heparin, to prevent life-threatening blood clots, but a new clinical trial found that over-the-counter aspirin is just as effective. The findings, presented today at the Orthopedic Trauma Association (OTA)...
by University of California, Los Angeles The study included a complementary translational approach with both preclinical in vitro studies and clinical studies using accessible PBMCs from HIV-1(−) participants (men and women) and people with HIV (PWH) with suppressed plasma viremia on TAF-based versus TDF-based ART. Credit: Theodoros Kelesidis New UCLA-led research suggests that antiretroviral drugs called TAF...
Lisa Jhung January 10, 2023 If your patients vowed to start exercising this year, here’s another incentive to help them stick to their guns: They could protect themselves from potentially devastating COVID-19 outcomes like hospitalization and even death. The evidence is piling up that physical activity can lower the risk of getting very sick from COVID. The CDC,...
Carolyn Crist January 12, 2023 Two classes of drugs may be more effective than others for the treatment of gastroparesis, though the overall quality of evidence remains low to moderate and additional data are needed, according to a new report. Oral dopamine antagonists and tachykinin-1 antagonists appear superior to placebo, finds the study. In addition, some drugs rank higher...
by La Jolla Institute for Immunology The researchers grouped antibodies into communities (see color-coded groups above) based on precisely where the antibodies target the RBD. The new study highlights how some communities maintain their neutralizing power against Omicron lineage BA.1. Credit: Saphire Lab, LJI A new study led by scientists at La Jolla Institute for...
by Garvan Institute of Medical Research A graphic representation of osteoporosis. Credit: Garvan Institute of Medical Research People at high risk of fracture who also have complex or multiple chronic medical conditions are less likely to receive treatment for the underlying osteoporosis and also have poorer health outcomes, according to a new study from the Garvan Institute of Medical Research. These patients have...
by Cedars-Sinai Medical Center Credit: Pixabay/CC0 Public Domain Phone calls from a nurse may improve survival for patients treated for heart failure, according to a new study by investigators from the Smidt Heart Institute at Cedars-Sinai. Heart failure occurs when the heart does not pump enough blood to support the organs. Investigators at Cedars-Sinai have...
By UNIVERSITY OF LEEDS JANUARY 17, 2023 A rehabilitation program that helps people with long COVID reduce their symptoms and increase activity levels has shown “impressive” results. The program is based on a gradual or paced increase in a patient’s physical activity. The findings showed that before the start of the program, patients were reporting an average...
