by Massachusetts General Hospital ICB increases GBM vascular leakage and induces brain edema. MR T2-weighted-Fluid-Attenuated Inversion Recovery (T2-FLAIR) images obtained from a recurrent GBM patient (A) before and (B) after 4 mo of anti-PD-L1 (MEDI4763; NCT02336165) treatment show increased edema after ICB treatment. In addition to ICB-induced inflammation, this change may be due in part...
by Homa Shalchi, Baylor College of Medicine Credit: Pixabay/CC0 Public Domain In the ongoing research and treatment of diabetes, the focus is typically on the two forms of the disease that dominate public awareness. Type 1 has a stronger genetic component that requires insulin therapy for life; type 2 is frequently associated with obesity and lack of...
by Nina Bai, Stanford University Medical Center Graphical abstract. Credit: Journal of Clinical Investigation (2022). DOI: 10.1172/JCI163735 Stanford Medicine researchers have discovered a possible new way to treat pain without the use of opioids. By targeting a specific area of a well-known pain receptor, they were able to reduce pain sensitivity in mice without affecting the receptor’s other functions,...
by Benjamin Boettner, Harvard University The Wyss Institute’s eRapid electrochemical sensor platform enables the multiplexed, fast, and inexpensive detection of biomarker molecules specific for infectious and other diseases at the point-of-care. Credit: Wyss Institute at Harvard University Not all SARS-CoV-2 infections are created equal. We have learned this through multiple virus waves are taking their...
by UT Southwestern Medical Center Credit: Pixabay/CC0 Public Domain A study of retired professional football players by researchers at UT Southwestern Medical Center has found that their cognitive abilities did not differ significantly from a control group of similarly aged men who did not play football, nor did those abilities show significant change over one...
by Allessandra DiCorato, Massachusetts Institute of Technology Fluorescence microscopy image of brain tissue from a model of Alzheimer’s, showing tau tangles (red), amyloid plaques (white), RNA (green), and cell nuclei (blue). Credit: Zeng H, Huang J, Zhou H, et al. A common sign of Alzheimer’s disease is the excessive buildup of two types of protein...
by National Institutes of Health Credit: Neuron (2023). DOI: 10.1016/j.neuron.2023.01.007 New research offers clues about the biology of cells in the spinal cord that die off in amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. A team of researchers supported by the National Institutes of Health has found evidence linking motor neurons’ large cell size and supporting...
Scientists suggest patient’s own cells could be grown in the lab and used to repair stroke or trauma injuries In the study, human brain tissue was transplanted into the brains of adult rats. Photograph: Zoonar GmbH/Alamy Hannah Devlin Science correspondent @hannahdev Fri 3 Feb 2023 04.57 EST Blobs of human brain tissue have been transplanted...
Solskin/Getty Images A leak of the fluid that protects and supports the brain can cause “brain sagging,” which is associated with the same behavioral symptoms as a less common form of dementia. A new study suggests that surgically fixing such leaks can reverse the symptoms. However, the research also found that it is not always possible to...
Anne Trafton | MIT News Office Publication Date: February 2, 2023 PRESS INQUIRIES Caption: A new MIT study explains why dendritic cells (green) in lymph nodes that drain from the lungs fail to stimulate killer T cells (white) to attack lung tumors.Credits: Courtesy of the researchers Immunotherapy — drug treatment that stimulates the immune system...
