Story by John Lauerman • Yesterday 3:21 PM (Bloomberg) — Merck & Co.’s Covid-19 pill is giving rise to new mutations of the virus in some patients, according to a study that underscores the risk of trying to intentionally alter the pathogen’s genetic code. BARI, ITALY – JANUARY 11: Doctor holds in her hands the...
by Jeff Renaud, University of Western Ontario Graphical Abstract. Credit: (2023). DOI: 10.1093/braincomms/fcad018 While it’s especially common in older adults, tinnitus—a potentially devastating ringing in the ears—can affect people of all ages. Most often described as consistent buzzing, hissing or humming, tinnitus is usually caused by an underlying condition, like age-related hearing loss, an ear injury...
by SRI International Monomeric and tetrameric MGS4 have similar binding, internalization and subcellular location. a, Binding and internalization of tetrameric MGS4_V1 and monomeric MGS4_V2 on live H1299 cells in culture. Cells were incubated with the peptide conjugated to streptavidin-phycoerythrin for 1 h at 37 °C. Non-internalized peptide was removed and the cells were analyzed by flow cytometry....
by Laurie Fickman, University of Houston Antibody pair selection for construction of ALCAM LFA. (A) 57 antibody pairs (eight types of antibodies were tested in all combinations and with each serving as detection Ab-the antibody conjugated onto the nanophosphors and as capture Ab-the antibody immobilized onto the LFA strip) were tested for ALCAM LFA performance,...
by Columbia University Young and old blood stem cells. Rejuvenating the stem cells that create all blood cells could potentially slow aging. Credit: Emmanuelle Passegué Young blood has a rejuvenating effect when infused into older bodies, according to recent research: Aging hearts beat stronger, muscles become stronger, and thinking becomes sharper. Many scientists are looking for...
by Silvia Cernea Clark, Rice University Schematic representation of the mechanisms of action of antifungal MMs. MMs bind cardiolipin and phosphatidylglycerol in the inner mitochondrial membrane, destabilizing the electron transport chain. This leads to increased electron leakage and superoxide radical formation, causing oxidative stress. Consequently, ATP synthesis and mitochondrial membrane potential are reduced. ATP-dependent calcium transporters...
Ewen Callaway A nanoparticle vaccine from South Korean firm SK bioscience, approved in 2022. Nik Spencer/Nature. Adapted from A. C. Walls et al. Cell 183, 1367–1382 (2020). Vaccines against the coronavirus SARS-CoV-2 have been given to billions of people to protect them from COVID-19, and have saved more than 20 million lives. But viral variants...
AMERICAN CHEMICAL SOCIETY Most cancer diagnostic techniques rely on uncomfortable and invasive procedures, such as biopsies, endoscopies or mammograms. Blood samples could be a less unpleasant option, though only a few forms of the disease can currently be diagnosed this way. But now, researchers reporting in ACS Sensors have developed an easy-to-use method that can detect small amounts of...
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO The process of cellular aging is multifactorial, and its investigation involves several knowledge areas. Finding ways to protect cells against damage is a key focus. A group of researchers recently achieved noteworthy progress in this regard, as evidenced by an article published in Scientific Reports, a Springer Nature journal. According to...
KAROLINSKA INSTITUTET VIDEO: ARFID IS STRONGLY INFLUENCED BY GENETIC FACTORS, ACCORDING TO A NEW STUDY EXAMINING THIS RELATIVELY NEW TYPE OF EATING DISORDER. LISA DINKLER, A POSTDOCTORAL RESEARCHER AT THE DEPARTMENT OF MEDICAL EPIDEMIOLOGY AND BIOSTATISTICS AT KAROLINSKA INSTITUTET EXPLAINS MORE ABOUT ARFID AND THE STUDY SHE CARRIED OUT. CREDIT: KAROLINSKA INSTITUTET ARFID is strongly...
