by Max Planck Society The scientists took images of the womens’ brain with positron emission tomography (PET) at different cycle times. Credit: MPI CBS Scientists led by Julia Sacher from Max Planck Institute for Human Cognitive and Brain Sciences and Osama Sabri from the Leipzig University Hospital have discovered in an elaborate patient study that...
A TREM2 activating antibody with a transport vehicle that could boost the metabolism and function of brain microglia
by Ingrid Fadelli, Medical Xpress Images showing the architecture of our ATV:TREM2 molecule (a) images showing elevation of microglia proliferation in the brain of mice treated with ATV:TREM2 (b) a super resolution image of microglia caught in the act of proliferation, shown here is microglia in vivo in cytokinesis phase post ATV:TREM2 dosing; cell nuclei...
Researchers revisit potent drug as promising treatment for acute leukemia
by National University of Singapore Chemical screening using the GIMAP enhancer reporter system. (A) Overview of the chemical screening strategy. Using a liquid handling workstation, 2,961 compounds from 3 chemical libraries, a negative control (dimethyl sulfoxide [DMSO]) and a positive control (THZ1), were added to Jurkat cells that stably expressed the GIMAP enhancer reporter construct....
CAN A COUGH SYRUP DRUG HELP PEOPLE QUIT SMOKING?
The researchers developed a new machine learning method, where computer programs analyze data sets for patterns and trends, to identify the drugs and say that some of them are already being tested in clinical trials. Cigarette smoking is risk factor for cardiovascular disease, cancer, and respiratory diseases and accounts for nearly half a million deaths in the United...
RNA Lipid Nanoparticle Engineering Stops Liver Fibrosis in its Tracks, Reverses Damage
Since the success of the COVID-19 vaccine, RNA therapies have been the object of increasing interest in the biotech world. These therapies work with your body to target the genetic root of diseases and infections, a promising alternative treatment method to that of traditional pharmaceutical drugs Lipid nanoparticles (LNPs) have been successfully used in drug delivery...
Researchers map the effects of dietary nutrients on disease
by The Francis Crick Institute Researchers gathered experimental data to put into the model by measuring the levels of gene expression in liver and liver tumours from mice that had been fed either ‘healthy’ diets or ‘unhealthy’ diets, rich in fats and sugars. Credit: The Francis Crick Institute Researchers at the Francis Crick Institute and King’s College...
Fresh questions about oxytocin as the ‘love hormone’ behind pair bonding
by University of California, San Francisco CPK model of the Oxitocin molecule. Credit: CC0 Turning a decades-old dogma on its head, new research from scientists at UC San Francisco and Stanford Medicine shows that the receptor for oxytocin, a hormone considered essential to forming social bonds, may not play the critical role that scientists have assigned to...
Non-invasive neurotechnology shown to reduce symptoms of insomnia and improve autonomic nervous system function
by Atrium Health Wake Forest Baptist Cereset Research with Standard Operating Procedures (CR-SOP) is the evolution of HIRREM, or high-resolution, relational, resonance-based electroencephalic mirroring, a noninvasive, closed-loop technology that uses scalp sensors to monitor brainwaves and software algorithms to translate specific frequencies into audible tones of varying pitch. Credit: Wake Forest University School of Medicine A good...
Evolutionary history of SARS-CoV-2 leads to a universal vaccine already being tested in animal models
by Delthia Ricks, Medical Xpress SARS-CoV-2 S protein evolution was used to guide the design of the Span sequence.(A) Phylogenetic trees are shown for 2675 S protein amino acid sequences from the NCBI database. (B) Proportion of the top five mutations and the E484K mutation for the amino acid sequences analyzed. (C) Linear diagram of the...
Another promising step toward non-hormonal male contraceptives
by American Chemical Society Graphical abstract. Credit: Journal of Medicinal Chemistry (2023). DOI: 10.1021/acs.jmedchem.2c01731 Despite birth control existing for decades, almost none of the options specifically target sperm cells. Researchers are now developing approaches that target testosterone or otherwise interrupt the sperm’s ability to fertilize an egg, yet these may not work for everyone. But now, researchers publishing in the Journal of...