by Christin Senior, University of Central Florida Pipeline for calculation of TH-IR axon density. Six frames within each region of interest (ROI) were selected, converted to grayscale, thresholded using Otsu algorithm, skeletonized and the signal pixels were measured in each ROI to represent total length of axons travelled in each ROI. Credit: Scientific Reports (2023). DOI: 10.1038/s41598-023-27727-9 A team...
by Amy Norton An experimental blood test may be able to catch a dozen different types of cancer with a high degree of accuracy—including some that are particularly tricky to detect, a preliminary study suggests. Researchers found that the blood test was usually on the money in detecting “signals” from 12 cancers. Importantly, the test was highly...
by Waseda University Researchers have developed a novel, wireless, PT-symmetric wearable resonator that can detect tear glucose and blood lactate levels in the micromolar range. The resonator is composed of an inductance–capacitance–resistance (LCR) reader and an LCR sensor with an enzyme-based chemiresistor. The setup has a high quality (Q) factor, making it highly sensitive. Credit: Professor Takeo...
by SWOG Cancer Research Network Credit: Unsplash/CC0 Public Domain Results from the S1609 DART clinical trial, which tested an immunotherapy combination of ipilimumab plus nivolumab in 53 cohorts of patients with rare cancers, are being reported for five cohorts of patients who had rare gynecologic cancers. In three of those five cohorts—the cohorts for clear cell ovarian...
by The Scripps Research Institute A biologic (abzyme) developed by Scripps chemists converts the ultra-potent opioid carfentanil (left) to a weaker version (right) by stabilizing the reaction’s transition-state (center). Utilizing abzymes could lead to new ways for treating synthetic opioid overdose. Credit: Kim Janda, PhD, Scripps Research A new therapeutic designed by Scripps Research chemists can alter the molecular structure of...
by Duke University A super-powerful MRI merged with light-sheet microscopy allows researchers to create a high-definition wiring diagram of the entire brain in mice. Credit: Duke Center for In Vivo Microscopy Magnetic resonance imaging (MRI) is how we visualize soft, watery tissue that is hard to image with X-rays. But while an MRI provides good enough resolution to...
by Rockefeller University Blood vessels in the soft tissue between joints, during a rheumatoid arthritis flare-up. Credit: Laboratory of Molecular Neuro-oncology at The Rockefeller University It’s a well-documented medical mystery: Patients with gum disease are less likely to respond to rheumatoid arthritis treatments. But new research may help explain this link between gum disease and an otherwise disparate...
by Ben-Gurion University of the Negev Credit: Lawrencekhoo / Wikipedia. The green Mediterranean, high-polyphenols diet substantially regresses proximal aortic stiffness (PAS), a marker of vascular aging and increased cardiovascular risk. The green Mediterranean diet was pitted against the healthy Mediterranean diet and a healthy guideline-recommended control diet in the DIRECT PLUS, a large-scale clinical intervention trial. Researchers found...
by Massachusetts Eye and Ear Infirmary VPA/MYC synergistically reprogram adult SCs for HC-like cell regeneration. (A) A schematic diagram illustrating the experimental procedure of the cultured adult cochleae treated transiently by Dox to induce Myc and VPA to activate NICD (DV) and HC-like cell induction by Ad.Atoh1. (B and C) Vehicle (sterile water)/Ad.Atoh1 or Dox/VPA/Ad.Atoh1-treated adult (P30) rtTA/tet-Myc/Atoh1-GFP mice cochleae were labeled with MYO7A/GFP....
by Boston University School of Medicine Flow Diagram for Inclusion and Exclusion of Patients. Credit: JAMA Network Open (2023). DOI: 10.1001/jamanetworkopen.2023.8655 A thyroid storm is characterized by high-circulating thyroid hormones (severe hyperthyroidism) that leads to life-threatening acute end-organ damage, including neurologic dysfunction, cardiogenic shock, hepatic failure, cardiac arrhythmias, and high mortality. Current treatment guidelines recommend using the thyroid drug propylthiouracil...
