Computer simulations have helped researchers understand how pharmaceutically active substances cross cell membranes. These findings can now be used to discover new drug candidates more efficiently. There is a need for new drugs. For example, many antibiotics we have been using for a long time are becoming less effective. Chemists and pharmaceutical scientists are frantically searching for new active...
Month: <span>April 2023</span>
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How music can prevent cognitive decline
UNIVERSITÉ DE GENÈVE IMAGE: SIDE VIEW OF A BRAIN. IN BLUE, THE AREAS AFFECTED BY THE INCREASE IN GREY MATTER IN THE ELDERLY AS A RESULT OF MUSIC PRACTICE. CREDIT: © UNIGE – DAMIEN MARIE Normal ageing is associated with progressive cognitive decline. But can we train our brain to delay this process? A team...
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Novel allogeneic CAR T cell therapy delivers promising early results in patients with metastatic clear cell renal cell carcinoma
UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER ORLANDO ― The CD70-targeting allogeneic chimeric antigen receptor (CAR) T cell therapy, ALLO-316, demonstrated encouraging response rates and disease control rates in patients with metastatic clear cell renal cell carcinoma (ccRCC), according to results of a Phase I trial led by researchers at The University of Texas MD Anderson Cancer Center and presented...
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Emotion-focused therapy for bipolar disorder targets the amygdala
ELSEVIER Philadelphia, April 17, 2023 – A new study in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, published by Elsevier, identifies a therapeutic tool focused on emotional awareness that increased activation and connectivity of an emotion-regulating center in the brain. The therapy may be effective in the long-term treatment and relapse prevention of bipolar disorder (BD). Patients with BD experience...
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SpyLigation uses light to switch on proteins
UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE/UW MEDICINE IMAGE: MICROSCOPIC 2D AND 3D IMAGES OF UNIVERSITY OF WASHINGTON HUSKY LOGOS AND A DOG WERE MADE WITH A NEW CHEMISTRY TECHNIQUE, SPYLIGATION, THAT PRECISELY CONTROLS WHEN AND WHERE PROTEINS TURN ON. CREDIT: COLE DEFOREST RESEARCH GROUP Scientists can now use light to activate protein functions both inside and outside...
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Investigational drug may improve stem cell transplantation for multiple myeloma patients
WASHINGTON UNIVERSITY SCHOOL OF MEDICINE IMAGE: SHOWN ARE MULTIPLE MYELOMA CELLS FROM A PATIENT. AN INTERNATIONAL PHASE 3 CLINICAL TRIAL LED BY WASHINGTON UNIVERSITY SCHOOL OF MEDICINE IN ST. LOUIS HAS SHOWN THAT THE INVESTIGATIONAL DRUG MOTIXAFORTIDE — WHEN COMBINED WITH THE STANDARD THERAPY FOR MOBILIZING STEM CELLS — SIGNIFICANTLY INCREASED THE NUMBER OF STEM...
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University of Rochester researchers discover how to steer army of immune cells toward cancer
UNIVERSITY OF ROCHESTER MEDICAL CENTER Immunotherapy, particularly CAR T-Cell treatment for cancer, is extending the lives of many patients. But sometimes the therapy randomly migrates to places it shouldn’t go, tucking into the lungs or other noncancerous tissue and causing toxic side effects. A University of Rochester/Wilmot Cancer Institute team discovered the molecule responsible for guiding...
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Lipid molecules help to get stroke therapies into the brain
TOKYO MEDICAL AND DENTAL UNIVERSITY IMAGE: TOC-HDO, BUT NOT ASO, COULD BE EFFECTIVELY DELIVERED INTO ISCHEMIC BRAIN REGIONS, IN THE HYPERACUTE PHASE OF ISCHEMIC STROKE. CREDIT: DEPARTMENT OF NEUROLOGY AND NEUROLOGICAL SCIENCE, TMDU Researchers from Tokyo Medical and Dental University(TMDU) find that, when a stroke therapy is linked to a specific kind of lipid and injected...
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Leaps in artificial blood research aim to improve product safety, efficacy
OHIO STATE UNIVERSITY COLUMBUS, Ohio – Researchers have made huge strides in ensuring that red blood cell substitutes – or artificial blood – are able to work safely and effectively when transfused into the bloodstream. The key is to make the artificial blood molecules big enough so they don’t leak from blood vessels into tissue and cause...
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p21 facilitates chronic lung inflammation via epithelial and endothelial cells
IMPACT JOURNALS LLC IMAGE: FIGURE 5. EPITHELIAL AND ENDOTHELIAL CELL POPULATIONS MEDIATE P21-DEPENDENT INFLAMMATORY RESPONSES FOLLOWING CHRONIC LPS INHALATION. CREDIT: 2023 LEVI ET AL. “Our results implicate p21 as a critical regulator of chronic bronchitis and a driver of chronic airway inflammation and lung destruction.” BUFFALO, NY- April 17, 2023 – A new research paper was published on...