IMPACT JOURNALS LLC IMAGE: FIGURE 2: RAPAMYCIN PREVENTS CANCER BY SLOWING TUMOR PROGRESSION (HYPOTHETICAL SCHEMA). CREDIT: 2023 BLAGOSKLONNY “[…] long-term treatment with rapamycin slows down aging, a major risk factor for cancer […]” BUFFALO, NY- April 17, 2023 – A new research perspective was published in Oncotarget’s Volume 14 on April 14, 2023, entitled, “Cancer prevention with rapamycin.” The mTOR (Target...
Adding new vaccine type to leading immunotherapy dramatically reduced melanoma recurrence
by NYU Langone Health Credit: Unsplash/CC0 Public Domain The combination of an experimental mRNA vaccine with an immunotherapy reduced the likelihood of melanoma recurring or causing death by 44% when compared to immunotherapy alone, a new clinical trial shows. Led by researchers at NYU Langone Health and its Perlmutter Cancer Center, the randomized phase 2b trial involved men...
Metagenomic sequencing outperforms conventional tests to identify antimicrobial resistance in bloodstream infections
by European Society of Clinical Microbiology and Infectious Diseases Credit: CC0 Public Domain Metagenomic sequencing can provide rapid and actionable antimicrobial resistance predictions to treat bloodstream infections much faster than conventional laboratory tests, and has the potential to save lives and better manage the use of antibiotics, according to new research being presented at this year’s European...
A highly sensitive, wearable piezoelectric blood pressure sensor for continuous health monitoring
by The Korea Advanced Institute of Science and Technology (KAIST) Schematic illustration of the overall concept for a wearable piezoelectric blood pressure sensor (WPBPS). Credit: The Korea Advanced Institute of Science and Technology (KAIST) A KAIST research team led by Professor Keon Jae Lee from the Department of Materials Science and Engineering and the College of Medicine of...
Researchers identify genes that can improve stroke diagnosis and treatment
by Claudia Coons, UC Davis Differential expression across time points. Differentially expressed genes (DEGs) across time points versus VRFC (0–24 h (TP1), 24–48 h (TP2), and >48 h (TP3)) in monocytes (A), neutrophils (B), and whole blood (C). Venn diagrams of the numbers of DEGs at each time point are shown on the left, and on...
A new breakthrough in Alzheimer’s disease research: Visualizing reactive astrocyte-neuron interaction
by Institute for Basic Science Fig. 1. Augmentation of acetate uptake, mediated by MCT1, facilitates Aβ-induced GABA release in reactive astrocyte. A. Blockade effect of MCT1 inhibitor on 14C-acetate uptake in primary cultured astrocytes. B. Blockade effect of MCT1 gene-silencing on 14C-acetate uptake in primary cultured astrocytes. C. Representative images displaying GFAP and MCT1 expressions in primary...
Extrachromosomal DNA detection in Barrett’s esophagus linked to cancer development
by Justin Jackson, Medical Xpress Study and analysis designs. a, Breakdown of the histological disease states among patients with Barrett’s esophagus in the Cambridge selected cross-sectional study, representing the highest disease state for that patient. NDBE, non-dysplastic Barrett’s esophagus. b, The FHCC cohort consisted of 80 patients for whom biopsies were collected prospectively. The cohort...
AI technique identifies people who would benefit most from treatment to reduce future cardiovascular disease risk
by Enrique Rivero, University of California, Los Angeles Credit: Pixabay/CC0 Public Domain New UCLA research suggests that a novel machine-learning technique known as “causal forest” was about five times more efficient than the current clinical practice of treating patients with high blood pressure. Under current practice, physicians treat patients with high blood pressure under the assumption that people at...
Long COVID smell loss linked to changes in the brain
by University College London A) In hot colors, significant clusters overlaid on the MNI template showing increased functional connectivity between the right OFC seed and the right visual association cortex/fusiform gyrus, in the CoV+Anos-Long group compared to the Cntrl group. B) Mean Z values extracted from the right fusiform cluster for each group. C) Significant clusters...
Statin use is associated with lower risk of stroke in patients with atrial fibrillation
by European Society of Cardiology Credit: Unsplash/CC0 Public Domain A region-wide study in more than 50,000 patients with atrial fibrillation has found reduced risks of stroke and transient ischemic attack in those who started statins within a year of diagnosis compared with those who did not. The findings are presented at EHRA 2023, a scientific congress of...