by Win Reynolds, Northwestern University Credit: CC0 Public Domain Adoptive cell therapy (ACT) has become a promising immunotherapy tool to help treat advanced melanoma. The therapy, which harnesses immune cells collected from the patient’s own tumors, could provide a new treatment option to cancer patients, potentially bypassing radiation therapies and harsh chemotherapy drugs. For the first...
by Society of Nuclear Medicine Bioluminescence images of untreated and treated mice with human B cell lymphoma. Optimal results occurred with 8.51 MBq of [177Lu]Lu-ofatumumab (bottom row). Ofa = ofatumumab. Credit: Journal of Nuclear Medicine (2022). DOI: 10.2967/jnumed.122.264816 A new nuclear medicine therapy can cure human non-Hodgkin’s lymphoma in an animal model, according to research published in the April issue...
by HRI Graphical abstract. Credit: Circulation Research (2023). DOI: 10.1161/CIRCRESAHA.122.322418 Atherosclerosis is the main underlying cause of cardiovascular disease (CVD). In this process, plaque made of fat, cholesterol, calcium, and other substances builds up on the artery walls. Plaque that remains on the artery wall is considered ‘stable’, although it can harden and narrow the arteries over time....
by American College of Physicians Credit: Pixabay/CC0 Public Domain An emulated randomized trial performed using observational data from more than 43,000 adults with primary hyperparathyroidism found that parathyroidectomy had no estimated effect on long-term kidney function in older adults when compared to observation. However, early parathyroidectomy may preserve kidney function in patients younger than 60 years...
by SingHealth A map of CD8+ T cells, in different states, from primary and metastatic tumors by single cell RNA sequencing. Credit: Quah et al., Nature Communications A research team led by the National Cancer Centre Singapore (NCCS) with members from Duke-NUS Medical School, KK Women and Children’s Hospital, A*STAR’s Singapore Immunology Network (SIgN), the University of...
by Melissa Rohman, Northwestern University Credit: Pixabay/CC0 Public Domain Repeat radiation therapy combined with the monoclonal antibody drug bevacizumab extended progression-free survival in patients with recurrent glioblastoma, according to findings from a recent clinical trial published in the Journal of Clinical Oncology. Jeffrey Raizer, MD, adjunct professor in the Ken and Ruth Davee Department of Neurology’s Division...
by Josh Barney, University of Virginia The discovery of a gene that can determine risks for heart attacks and other vascular diseases could lead to new treatments for those conditions, and maybe even prevention. Credit: Emily Faith Morgan, University Communications/University of Virginia University of Virginia School of Medicine researchers have identified a gene that plays a crucial role...
by American Institute of Physics The complex interplay between phospholipid and hyaluronic acid self-assembly in solution, and the molecular weight of hyaluronic acid, determine surface affinity and the formation of a protective film on cartilage. Credit: Kangdi Sun, Tooba Shoaib, Mark W. Rutland, Changwoo Do, and Rosa M. Espinosa-Marzal Osteoarthritis is a degenerative joint disease caused...
by Justin Jackson, Medical Xpress Comparisons of microbial compositions between baseline and follow-up. (a) aPCoA of the Bray‒Curtis distance plot for baseline and follow-up after adjusting for hypertension, medication use, and alcohol and tea drinking. (b) α-Diversity differences between baseline and follow-up for stratified health statuses (HB, n = 21; HF, n = 15; LHB, n = 19; LHF, n = 27). (c)...
by University of California, Los Angeles Credit: Pixabay/CC0 Public Domain Research led by scientists at UCLA Jonsson Comprehensive Cancer Center found that responses to a type of immunotherapy called PD-1 checkpoint blockade in patients with advanced melanoma depended on whether or not they had previously received another immunotherapy—CTLA-4 blockade—as well as other factors. Their findings, based on...
