Month: <span>April 2023</span>

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Superhydrophobic biosensors could measure sweat vapors on the body

Sweat contains biomarkers that help doctors make health diagnoses. Wearable sensors can monitor a person’s perspiration rate and provide information about the skin, nervous system activity and underlying health conditions. But not all sweat is created equal, and some cannot be measured with current sensors. A newly developed superhydrophobic biosensor could be used as a...

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Bacterial agent opens new therapeutic options for Wilson’s disease

by Helmholtz Association of German Research Centres Graphical abstract. Credit: Gastroenterology (2023). DOI: 10.1053/j.gastro.2023.03.216 A specific molecule excreted by methane-oxidizing bacteria could be most suitable for therapy against Wilson’s disease (WD). This is what researchers led by Helmholtz Munich scientist Hans Zischka have found in a new study. In a WD rat model, the molecule called ARBM101 lowered copper...

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Scientists uncover new mechanisms and therapeutic possibilities for heart failure

by Temple University Credit: Circulation Research (2023). DOI: 10.1161/CIRCRESAHA.122.321583 Greater awareness and advances in treatment have greatly improved survival rates following heart attack. With more survivors, however, has come the challenge of managing long-term impacts on heart function, especially chronic heart failure, in which the heart gradually loses its ability to pump blood. Mortality among individuals affected by...

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Researchers develop technology to treat Charcot-Marie-Tooth (CMT) disease

by DGIST (Daegu Gyeongbuk Institute of Science and Technology)  Credit: DGIST (Daegu Gyeongbuk Institute of Science and Technology) The research team led by Professor Minseok Kim from the Department of New Biology at DGIST (President Yang Kuk) has developed a technology that can treat Charcot-Marie-Tooth (CMT) disease, an incurable hereditary disease, with electric stimulation instead of drug...

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Microrobot capable of forming neural networks and sectioning hippocampal tissues in vitro

by DGIST (Daegu Gyeongbuk Institute of Science and Technology)  Credit: DGIST (Daegu Gyeongbuk Institute of Science and Technology) The research team led by Professor Hongsoo Choi from DGIST in the Department of Robotics and Mechatronics Engineering has developed a microrobot capable of forming neural networks and sectioning hippocampal tissues in an in vitro environment in an ex...

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Search for a major depression trigger reveals a familiar face: Discovery opens new possibilities for treatments

by University of Florida A model shows how glycine molecules (teal) interact with brain cell receptors called GPR158 to influence the nervous system. The dotted lines show hydrogen bonds and weak electrical field attractions that start the signal. Credit: Martemyanov lab at The Wertheim UF Scripps Institute. A common amino acid, glycine, can deliver a...

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New drug delivery method harnesses clotting to target tumors

by Will Cushman,  University of Wisconsin-Madison Characterization of the thrombosis-mediated navigation system. (A) Schematic of the thrombosis-mediated navigation system for P-aPD-1. Truncated tissue factor–Arg-Gly-Asp (RGD) (tTF-RGD), administered either by intravenous (i.v.) or p.t. routes, targets tumor neovasculature endothelial cells and initiates coagulation cascade to recruit anti–programmed cell death 1 (PD-1) antibody–conjugated platelets (P-aPD-1). P-aPD-1 is activated...

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Using bone marrow precursor cells instead of transplantation to regenerate bone

by Stefanie Seltmann, Berlin Institute of Health Imaging mass spectrometry analysis of murine critical-size femur fractures treated with in vitro engineered human stromal cell–derived cartilage discs. (A to D) Segmentation maps were generated from the mass-to-charge (m/z) value spectra of whole tissue sections of BMSC-derived (A and B) and ATSC-derived (C and D) transplant groups...