Megan Brooks April 21, 2023 An experimental neural cell therapy is safe and led to greater than 90% reduction in seizures in two patients with drug-resistant mesial temporal lobe epilepsy (MTLE) in the first-in-human test of the novel therapy. “It is notable that the early significant seizure reduction observed in this study appears to be durable in...
Month: <span>May 2023</span>
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Failed cancer therapy revived as powerful tumor killer when combined with newer drugs
16 MAY 2023 5:50 PM BY MITCH LESLIE Drugs that prevent new blood vessel growth may make tumors more vulnerable to checkpoint inhibitors. ELLA MARU STUDIO/SCIENCE SOURCE Patients with a type of liver cancer known as hepatocellular carcinoma (HCC) often face an anxious wait after their tumor is removed. In up to half of these...
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Artificial intelligence provides new insight into preventing human disease
A molecular machine, which plays an essential ‘cargo’ role in controlling the delivery of proteins to the surface of human cells, and is implicated in several diseases, has been identified in a landmark study using artificial intelligence (AI). The research, led by an international team of scientists, is published in Cell. Researchers at the Universities of...
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Researchers reveal DNA repair mechanism
by NYU Langone Health The study enzyme RNAseHII repairs DNA by riding along on the enzyme that reads the genetic code, RNA polymerase, and cutting out (see scissors) misplaced code letters when it “sees” them in bacterial genetic material. Credit: Cell Press A new study adds to an emerging, radically new picture of how bacterial cells...
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Bioengineering active immunotherapy for personalized cancer treatment
by Thamarasee Jeewandara, Medical Xpress Design of IL2-ep13nsEV and its utilization in treating breast cancer. To generate this active immunotherapy, the sEVs from autologous DCs are engineered with surface membrane–bound IL2 by expressing IL2-MFG-E8. This personalization of DC-derived sEV (p13nsEV) is achieved by loading lysed surgically harvested breast cancer cells onto engineered autologous DCs followed...
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Common Gut Bacteria Linked to Parkinson’s Disease
Megan Brooks May 12, 2023 A common gut bacteria may play a role in the development of Parkinson’s disease (PD) by causing aggregation of the alpha-synuclein protein, a key feature in the pathology of PD, a small study suggests. Environmental factors as well as genetics are also suspected to play a role in PD etiology, although the exact cause...
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Magnetic stimulation may improve the pain, nausea of diabetic gastroparesis
MEDICAL COLLEGE OF GEORGIA AT AUGUSTA UNIVERSITY IMAGE: AMOL SHARMA, MD CREDIT: MICHAEL HOLAHAN, AUGUSTA UNIVERSITY AUGUSTA, Ga. (May 16, 2023) – Magnetic stimulation of a group of nerves key to how our gut and brain communicate may help correct the conversation that goes awry in painful, debilitating diabetic gastroparesis, researchers say. Patients come to Amol Sharma, MD, because...
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Novel antibiotic succeeds in trial against hospital-acquired pneumonia
RUTGERS UNIVERSITY A Rutgers researcher leading a trial found that the novel combination antibiotic sulbactam-durlobactam combats dangerous pneumonia at least as well as the best currently approved treatment. The findings have led a unanimous expert committee to recommend that the Food and Drug Administration (FDA) approve the new drug, which could be available this summer to combat...
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Saturated fatty acids promote immune escape of oral cancers
MICHIGAN MEDICINE – UNIVERSITY OF MICHIGAN A team from the University of Michigan Rogel Cancer Center and School of Dentistry, led by Yu Leo Lei, D.D.S., Ph.D., have identified a mechanism in mice for how obesity affects some oral cancers’ ability to escape from the immune system. This study, published in Cell Reports, found that obesity helps to establish a type...
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Newly discovered RNA molecules hold promise for detecting and treating esophageal cancer
by Bill Lubinger, Case Western Reserve University A hairpin loop from a pre-mRNA. Highlighted are the nucleobases (green) and the ribose-phosphate backbone (blue). Note that this is a single strand of RNA that folds back upon itself. Credit: Vossman/ Wikipedia Irregularities in the body’s genetic coding to make proteins are linked to cancerous tumors. But most...