OSAKA UNIVERSITY IMAGE: ADMINISTERED RSPO3 AND RSPO3 SECRETED BY ENDOTHELIAL CELLS PROMOTE NEURITE OUTGROWTH AND NEUROPROTECTION BY SUPPRESSING TLR2, TLR4, AND TLR9-INDUCED INFLAMMATION IN MICROGLIA AND BY ACTING DIRECTLY ON NEURONS (A). RSPO3 STIMULATES NUCLEAR TRANSLOCATION OF Β-CATENIN, RESULTING IN THE DOWNREGULATION OF TLR4 EXPRESSION AND PROMOTION OF NEURITE OUTGROWTH (B). CREDIT: STROKE IN PRESS...
Microbubble macrophages track tumors
by Acoustical Society of America Attaching microbubbles to macrophages can create high-resolution and sensitive tracking images useful for disease diagnosis. Credit: Ashley Alva Macrophages, a type of white blood cell, defend the body by engulfing and digesting foreign particles, such as bacteria, viruses, and dead cells. The immune cells also tend to accumulate in solid...
Novel Rutgers COVID vaccine may provide long-lasting protection
by Rutgers University Novel Coronavirus SARS-CoV-2 Transmission electron micrograph of SARS-CoV-2 virus particles, isolated from a patient. Image captured and color-enhanced at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Credit: National Institute of Allergy and Infectious Diseases, NIH Animal studies indicate that a new COVID-19 vaccine developed at Rutgers may provide more durable protection...
Strong link between bone biomarkers and prostate cancer survival
by Stephanie Winn, UC Davis Credit: UC Davis Prostate cancer is the second leading cause of death in American men. Understanding the factors that influence patient outcomes is critical for improving treatment and survival rates. Research led by UC Davis Comprehensive Cancer Center reveals a link between bone metabolism biomarkers and survival in men with newly...
Team discovers new drugs with potential for treating world’s leading causes of blindness in AMD, other diseases
by University of California, Irvine Molecular mechanisms of stress resilience-enhancing drug (SRED) therapy. Retinal degeneration involves a complex, multifactorial combination of genetic factors and environmental exposures that accumulate over a lifetime and eventually overwhelm intrinsic stress resilience mechanisms, which can be enhanced pharmacologically by SREDs to alleviate disease and preserve vision. Credit: UCI School of Medicine...
AI runs 10,000 experiments a day on bacteria to speed up discoveries
By Michael Irving May 08, 2023 A new AI platform called BacterAI can conduct thousands of experiments per day to learn about bacteria, even without any prior knowledge Depositphotos Scientific work often involves sifting through enormous amounts of data, a task that’s overwhelmingly mundane for humans but a piece of cake for artificial intelligence. A...
The Trumpet: molecular biocomputing platform heralds a new path for medicine
From early detection and internal treatment of diseases to futuristic applications like augmenting human memory, biological computing, or biocomputing, has the potential to revolutionize medicine and computers. Traditional computer hardware is limited in its ability to interface with living organs, which has constrained the development of medical devices. Computerized implants require a constant supply of electricity,...
Researchers show that using a tumor’s own bacteria is a promising anticancer therapy
A novel approach to treating cancer uses bacteria that naturally reside within tumors to trigger a powerful anticancer immune responsePeer-Reviewed Publication JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY IMAGE: A BACTERIAL CONSORTIUM CONSISTING OF A-GYO, UN-GYO, AND AUN HAS HIGH ANTICANCER EFFICACY, TRIGGERING THE IMMUNE SYSTEM TO ATTACK TUMOR CELLS. CREDIT: EIJIRO MIYAKO FROM JAIST....
Anti-depressant agent KNT-127 reduces stress as well as depression
Scientists have developed a potential anti-depressant that exhibits anti-stressing as well as anti-depressant effects with minimal side effects Peer-Reviewed Publication TOKYO UNIVERSITY OF SCIENCE IMAGE: RESEARCHERS FROM JAPAN DEMONSTRATE THAT A DOP AGONIST, KNT-127, ALTERS THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS, HIPPOCAMPAL NEUROGENESIS, AND NEUROINFLAMMATION, TO EXHIBIT THERAPEUTIC AND PROPHYLACTIC EFFECTS CREDIT: “202102 FRONTAL PLANE OF THE BRAIN HIPPOCAMPUS”...
An unprecedented view of gene regulation
MIT engineers’ new technique analyzes the 3D organization of the genome at a resolution 100 times higher than before Peer-Reviewed Publication MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE, MA — Much of the human genome is made of regulatory regions that control which genes are expressed at a given time within a cell. Those regulatory elements can...