by Cell Press Credit: CC0 Public Domain Fecal microbiota transplants are the most effective and affordable treatment for recurrent infections with Clostridioides difficile, an opportunistic bacterium and the most common cause of hospital-acquired intestinal infections. However, attempts to treat chronic noncommunicable diseases such as ulcerative colitis and metabolic syndrome via fecal microbiota transplantation (FMT) have yielded...
by Anne Trafton, Massachusetts Institute of Technology Graphical abstract. Credit: ACS Central Science (2023). DOI: 10.1021/acscentsci.2c01471 Antibodies that can disarm a virus, known as neutralizing antibodies, are key to the body’s ability to fight off infection. MIT chemists have come up with a new way to identify these neutralizing antibodies in a blood sample, by analyzing how antibodies...
By Paul McClure May 09, 2023 An illustration of a protein tangle that leads to the death of nerve cells and is a hallmark of Alzheimer’s disease EMPA/Communications Biology Testing for protein clumps in spinal fluid is the conventional way of detecting Alzheimer’s disease, but it doesn’t provide information about the disease’s stage. In a...
By Paul McClure May 10, 2023 New research has used a specially-designed machine learning algorithm to identify unique combinations of metabolites that may be able to detect Parkinson’s disease early Depositphotos Parkinson’s disease (PD) is growing more rapidly than any other neurological disease, which makes its early detection so important. Researchers have developed a new machine-learning tool that shows promise...
By Michael Irving May 09, 2023 Scientists have discovered a new cause of cancer – a mutation in a specific gene that interferes with a cellular cleanup process Depositphotos Cancer can be the end result of a wide range of things that go wrong, and understanding how is key to prevention and treatment. Now, scientists...
Reviewed by Emily Henderson, B.Sc. May 9 2023 COVID-19, the disease resulting from SARS-CoV-2 infection, is associated with highly variable clinical outcomes that range from asymptomatic disease to death. For those with milder infections, COVID-19 can produce respiratory infection symptoms (cough, congestion, fever) and sensory phenotypes such as headache and loss of sense of smell....
by Weill Cornell Medical College Comparison of the PASC risks in the INSIGHT cohort versus in the OneFlorida+ cohort, from March 2020 to November 2021. The incident risk was measured by the adjusted hazard ratios (aHR) with 95% confidence intervals as shown in the main panel. The adjusted cumulative incidences (CIF) per 1000 patients in both...
by Catherine Diamond, Xi’an jiaotong-Liverpool University DNA being delivered into the nucleus of a stem cell – An artistic rendition of the study led by Dr Gang Ruan and selected as a supplementary cover art by the journal Nano Letters. Credit: American Chemical Society A recent study published in Nano Letters has introduced a new method for delivering particles...
by University of Pittsburgh Universal adaptor SNAP-CAR and SNAP-synNotch receptor function. a A benzylguanine motif (BG) is chemically conjugated to an antibody using a benzylguanine NHS ester. The BG-antibody conjugate then covalently binds to the extracellular SNAPtag enzyme through a self-labeling reaction. b SNAPtag receptors enable the targeting of multiple different antigens using the same receptor...
May 05, 2023 COPENHAGEN/LONDON (Reuters) – Novo Nordisk expects the oral version of its semaglutide drug to treat obesity to have similar efficacy as its Wegovy injection, with data from a late-stage clinical trial due before the end of June, a senior executive said on Thursday. Head of development Martin Holst Lange was discussing the trial called...
