by University of Oxford Change in mean hand pain in participants over the study period. (A) Recall at study visits of mean hand pain on a 0–10 NRS for the preceding 14 days before the baseline, and week 4, 12, 24, and 28 study visits. (B) Mean of recorded daily mean hand pain on a...
Month: <span>May 2023</span>
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Epic, Microsoft bring generative AI to EHRs
BROCK E.W. TURNER ylem, Wikimedia Commons HIMSS 2023 kicked off Monday in Chicago. Follow our live blog for the latest updates and happenings from the conference. Epic Systems is working with Microsoft to integrate generative AI technology into its electronic health record software for the first time, the companies said Monday. The announcement was made in conjunction with the...
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Hidden RNA repair mechanism discovered in humans
UNIVERSITY OF KONSTANZ Ribonucleic acids (RNAs) are single-stranded molecules that play an essential role in the cells of all living organisms. As “transcripts” of our genes, mRNAs, for example, are involved in the translation of genetic information by carrying in their own sequence the instructions for the creation of a protein. “In order to fulfil...
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New biologic effective against major infection in early tests
NYU LANGONE HEALTH / NYU GROSSMAN SCHOOL OF MEDICINE Researchers at NYU Grossman School of Medicine and Janssen Biotech, Inc. have shown in early tests that a bioengineered drug candidate can counter infection with Staphylococcus aureus – a bacterial species widely resistant to antibiotics and a major cause of death in hospitalized patients. Experiments demonstrated that SM1B74, an...
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Researchers ID novel treatment pathway for deadly pancreatic cancers
JOHNS HOPKINS MEDICINE IMAGE: THE HIGH MOBILITY GROUP A1 (HMGA1) PROTEIN FUNCTIONS AS A “MOLECULAR SWITCH” THAT “FLIPS ON” EXPRESSION AND SECRETION OF A CRITICAL GROWTH FACTOR, CALLED FGF19, IN PANCREATIC CANCER. TOGETHER WITH HMGA1, FGF19 PROMOTES TUMOR PROGRESSION AND FORMATION OF A DENSE WALL-LIKE STRUCTURE CALLED THE “STROMA”, WHICH PREVENTS THERAPY FROM REACHING TUMOR...
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Inflammation ‘brake’ gene may help reveal outcomes of kidney disease
by Garvan Institute of Medical Research Paradoxically, a gene variant that increases inflammation also has a protective effect on the kidneys. Seen here, kidney cell nuclei (blue) and an influx of immune regulatory cells (pink) that prevent damage in an injured kidney. Credit: Garvan A discovery about gene variants of an inflammation ‘brake’ brings scientists a step...
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Drug combination restores ability of leading treatment to signal for death of blood cancer cells
by NYU Langone Health Credit: Unsplash/CC0 Public Domain Despite the promise of new medications that promote cancer cell death in people with acute myeloid leukemia, leukemic cells often adopt features that let them evade the drugs’ effects within a year. Now, new research using human tissue samples and mouse models has found that resistance of leukemia cells to a widely...
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Study suggests that maintaining normal vitamin D levels may benefit patients with advanced skin cancer
by Wiley Credit: Unsplash/CC0 Public Domain New research indicates that for patients with advanced skin cancer, it may be important to maintain normal vitamin D levels when receiving immunotherapy medications called immune checkpoint inhibitors. The findings are published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society. Vitamin D has many effects on the body,...
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Individualized glycemic targets for older type 2 diabetes patients supported by cohort study
by Justin Jackson, Medical Xpress Credit: Unsplash/CC0 Public Domain An international group of researchers led by Monash University, Australia, supports clinical guideline recommendations for relaxed glycemic targets in older type 2 diabetes patients with results from a large cohort study. The research paper, “Dementia Risk in People With Type 2 Diabetes,” published in JAMA Neurology, looked for a cumulative association...