by King’s College London KCL-286 transcriptional neuronal signaling. KCL-286 binds to a retinoic acid receptor (RAR)β2/retinoid x receptor (RXR) heterodimer located at a retinoic acid response element (RARE). This results in activation of transcriptional pathways required for axonal regeneration. Credit: British Journal of Clinical Pharmacology (2023). DOI: 10.1111/bcp.15854 New orally available drug for spinal cord injury found to...
by Lori Solomon Among adults with overweight or obesity, the annual probability of weight loss of 5 percent or more was achieved by only one in 10, according to a study published online Aug. 7 in JAMA Network Open. Lyudmyla Kompaniyets, Ph.D., from the U.S. Centers for Disease Control and Prevention in Atlanta, and colleagues assessed...
AUGUST 8TH, 2023 CONN HASTINGS MEDICINE, PUBLIC HEALTH, UROLOGY Researchers at ETH Zurich have developed a bacteriophage system to identify and treat bacterial bladder infections. Bacteriophages are viruses that infect bacteria, but these microorganisms have fallen out of favor as a treatment method for infection since antibiotics came along. Well, antibiotics are looking increasingly shaky as bacteria...
WILEY New research published in The FASEB Journal indicates that increasing the expression of a particular gene may help to prevent bone loss associated with postmenopausal osteoporosis. For the study, investigators examined which genes are involved in turning precursor cells called bone marrow–derived mesenchymal stem cells (BMSCs) into cells that play a crucial role in bone formation. The screen...
WILEY In research published in Arthritis & Rheumatology, investigators developed and validated a tool called PRESTO that identifies patients with psoriasis who face an elevated risk for developing psoriatic arthritis and may therefore benefit from preventive therapies. Among 635 patients with psoriasis followed in the University of Toronto psoriasis cohort, 51 and 71 developed psoriatic arthritis during 1-year...
UNIVERSITÉ DE GENÈVE IMAGE: TAU IMAGING WITH 18F-FLORTAUCIPIR PET IN ALZHEIMER’S DISEASE. THE FIGURE SHOWS A PROTOTYPICAL TAU ACCUMULATION PATTERN, OBTAINED BY COMPARING TAU LOAD OF PATIENTS WITH ALZHEIMER’S DISEASE VS HEALTHY CONTROLS. THE BLUE-TO-WHITE COLOR SCALE INDICATES MORE PRONOUNCED TAU LOADS, WITH PINK-WHITE AREAS REPRESENTING THOSE WITH THE HIGHEST ACCUMULATION. CREDIT: © UNIGE Alzheimer’s...
HELMHOLTZ MUNICH (HELMHOLTZ ZENTRUM MÜNCHEN DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH)) IMAGE: THE IMAGE PROVIDES A CAPTIVATING VIEW OF THE INTRICACY AND INTERCONNECTEDNESS OF THE HUMAN SKULL. THROUGH THE USE OF ADVANCED TISSUE CLEARING TECHNIQUES AND IMAGING WITH A LIGHT SHEET FLUORESCENT MICROSCOPE, THE SAMPLE HAS BEEN LABELED TO HIGHLIGHT MYELOID IMMUNE CELLS (SHOWN...
UNIVERSITY OF CAMBRIDGE Scientists studying how poxviruses evade natural defences in human cells have identified a new approach to treatment that may be more durable than current treatments. This follows their discovery of how poxviruses exploit a cellular protein to evade the host cell defences, and thereby replicate and spread effectively. Existing drugs developed to...
THE HEBREW UNIVERSITY OF JERUSALEM IMAGE: A TEM VISUALIZATION OF THE PHAGE PASA16 WITH P. AERUGINOSA PA14. CREDIT: RONEN HAZAN [Jerusalem, Israel] – A new international study conducted by the Israeli Phage Therapy Center (IPTC) led by Prof. Ran Nir-Paz at Hadassah Hebrew University Medical Center and Prof. Ronen Hazan of the Faculty of Dental...
BRIGHAM AND WOMEN’S HOSPITAL Brigham researchers are working on a new approach to target autoimmunity in the brain leverages designer bacteria to make treatment safer and more effective Researchers from Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, have designed a probiotic to suppress autoimmunity in the brain, which occurs when the immune system attacks...
