Ellen Kurek August 03, 2023 SEATTLE — A family of blockbuster drugs for managing blood glucose — and now for promoting weight loss — has been linked to exacerbation of macular disease that frequently accompanies diabetes, new data show. Two studies presented at the 2023 annual meeting of the American Society of Retina Specialists have found that...
Month: <span>August 2023</span>
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33% of Type 1 Diabetes Patients Insulin-Free With Stem Cells
Miriam E. Tucker July 03, 2023 SAN DIEGO — An investigational allogeneic stem cell–derived pancreatic islet cell replacement therapy (VX-880, Vertex Pharmaceuticals) continues to show promise as a treatment for type 1 diabetes, according to the latest data, from six patients thus far. Two of the six are insulin-independent beyond 1 year after receiving the VX-880 infusions,...
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Setmelanotide Offers Significant, Long-Lasting Weight Loss
Nathalie Raffier July 13, 2023 MARSEILLE, France — Setmelanotide can lead to significant weight loss that lasts for at least 3 years, according to results presented at the latest French Pediatric Society conference. The treatment is effective for adults and children alike. Setmelanotide is the culmination of two decades of research involving the identification of genes involved in early-onset obesity and...
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Scientists Figured Out a Way to Control Human Genes With Electricity
BY TIM NEWCOMB PUBLISHED: AUG 2, 2023 Comstock//Getty Images Dubbed a “missing link,” a team of researchers developed an “electrogenetic interface” to control genes. The initial effort uses a battery-powered device to send electrical currents that activate a response in a targeted gene The research team believes the electrogenetic interface system offers benefits for future gene or cell therapies....
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Study: Booster dose of mRNA COVID vaccine prompts strong T cell response in immunocompromised patients
by Delthia Ricks , Medical Xpress T cell responses to ancestral mRNA vaccine doses over time. (A) Gating on non-naïve/memory CD4+ and CD8+ T cells. Numbers indicate the percentage of the previous gate. (B) Comparison of pre- and postbooster CD8+ to CD4+ net-frequency ratio in response to Omicron full spike with indicated fold changes. (C)...
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Gut microbiome discovery could lead to new drug addiction treatments
By Paul McClure August 03, 2023 A study has found a link between the gut microbiome and cocaine use, including the cravings that come following withdrawal Depositphotos A new study has provided the first evidence of a link between the gut microbiome and cocaine use and the cravings that follow withdrawal. The findings open the...
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Microneedle Patch for Antibiotic-Free Acne Treatment
AUGUST 1ST, 2023 CONN HASTINGS DERMATOLOGY, MATERIALS, MEDICINE Researchers at the University of Hong Kong have developed a microneedle patch for the drug-free treatment of skin infections, such as acne. Acne is often treated using antibiotics, but these have limited effectiveness over the long term and can result in drug-resistant bacteria. In an effort to develop...
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Novel liquid metal nanoparticles for cancer photoimmunotherapy
JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY IMAGE: A VERSATILE LIQUID METAL (LM) GALLIUM-INDIUM ALLOY HAS BEEN USED TO DEVELOP A NOVEL LM NANOPARTICLE THAT HARBORS AN IMMUNOMODULANT AND AN IMMUNE CHECKPOINT INHIBITOR, ANTI-PD-L1. UPON IRRADIATION BY NEAR INFRA-RED LIGHT, ANTI-PD-L1 SPECIFICALLY BINDS TO THE CANCER CELL, WHILE IMMUNOSTIMULANTS ACTIVATE T AND DENDRITIC CELLS. THIS...
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Immune cells that fight cancer become exhausted within hours of first encountering tumors
Published: August 3, 2023 11.01am EDT Authors Mary PhilipAssistant Professor of Medicine and Pathology, Vanderbilt University Michael RudloffMD-Ph.D. Candidate in Molecular Pathology and Immunology, Vanderbilt University This microscopy image shows a cytotoxic T cell (blue) attacking a cancer cell (green) by releasing toxic chemicals (red). Alex Ritter and Jennifer Lippincott Schwartz and Gillian Griffiths/National Institutes of...
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New technique offers improved diagnostic precision, possible personalized therapy for common arrhythmia
by Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.) Schematic representation of the progression of electromechanical remodeling of the heart atria during atrial fibrillation, indicating at each disease stage the probability of restoring normal rhythm after an uninterrupted atrial fibrillation episode. Credit: CNIC A multidisciplinary study led by scientists at the Centro Nacional de Investigaciones...