by Columbia University Irving Medical Center Credit: Cell Metabolism (2023). DOI: 10.1016/j.cmet.2023.06.014 Warfarin, a widely used blood thinner, appears to have potent anti-cancer properties, according to a study by Columbia University researchers. The study, conducted in human cells and in mice, found that warfarin stops tumors from interfering with a self-destruct mechanism that cells initiate when they detect mutations...
by Deutsches Zentrum für Infektionsforschung Credit: Journal of Hepatology (2023). DOI: 10.1016/j.jhep.2023.07.003 Affecting hundreds of millions of people, chronic hepatitis B is a widespread global health problem for which there is as yet no cure. In a preclinical study involving the German Center for Infection Research (DZIF), Heidelberg University Hospital, University Medical Center Hamburg-Eppendorf and the US company Vir...
MAX PLANCK FLORIDA INSTITUTE FOR NEUROSCIENCE IMAGE: INSULIN-LIKE GROWTH FACTORS (IGF1/IGF2-CYAN SPHERES) ARE RELEASED FROM THE POSTSYNAPTIC COMPARTMENT OF A SYNAPSE DURING PLASTICITY. TO UNDERSTAND HOW IGF1 AND IGF2 PROMOTE MEMORY FORMATION, TU ET AL. DEVELOPED A BIOSENSOR TO DETECT THE ACTIVITY OF THE IGF1-RECEPTOR DURING SYNAPTIC PLASTICITY, THE CELLULAR PROCESS THAT STRENGTHENS CONNECTIONS BETWEEN...
by Elsevier Diagram of neuroinflammation in endometriosis. Researchers propose that IL-1β activates IL-1 type 1 membrane receptor (IL-1R1) in endometrial stromal cells, predominantly via the c-Jun N-terminal kinase (JNK) pathway, to promote neurotrophin and neurotrophin receptor (NTR) production and signaling, which in turn activate neurogenesis and pain. Parallel pathways promote IL-6 production and IL-1β autoregulation, potentially...
by The Scripps Research Institute Researchers showed that PIEZO2 receptors in sensory neurons control the rate of gut transit. In this fluorescently stained microscopy image, nerve endings stemming from the dorsal root ganglia that express the PIEZO2 protein are shown in cyan, and the nuclei of enteric neurons are shown in magenta. Credit: M. Rocio Servin-Vences (Scripps Research). Gastrointestinal and...
by Sarah C. P. Williams, Stanford University Credit: Pixabay/CC0 Public Domain It’s one of the mysteries of nature: How does the axolotl, a small salamander, boast a superhero-like ability to regrow nearly any part of its body? For years, scientists have studied the amazing regenerative properties of the axolotl to inform wound healing in humans. Now,...
by Ingrid Fadelli , Medical Xpress The morphological consequences of the five-ligand cocktail added to cultured human astrocytes. Individual cell traces are highlighted in white and demonstrate the ability of the ligands to induce a more complex and branched astrocyte morphology. Credit: Nature Neuroscience (2023). DOI: 10.1038/s41593-023-01375-8 Astrocytes are a type of glial cell in the central...
by University of Copenhagen Brainstem projection targets from Chx10-PPN neurons. Credit: Nature Neuroscience (2023). When a hunting dog picks up the scent of a deer, it sometimes freezes. On the spot. The same thing can happen to people who need to concentrate on a challenging task. Now researchers have made a discovery that adds to our knowledge...
Nancy A. Melville July 31, 2023 Patients with acute tubulointerstitial nephritis (AIN), a difficult-to-diagnose allergic reaction in the kidneys, show substantial increases in the protein CXCL9 in their urine, suggesting an essential, fast, and easy-to-test biomarker that could replace the more time-consuming kidney biopsy. “Our data show that in patients with suspected AIN the urine biomarker CXCL9 can significantly...
By Paul McClure August 02, 2023 Clinical trials of a novel non-opioid analgesic have found that it reduces acute postoperative pain Depositphotos Clinical trials of a novel non-opioid analgesic have found it to be effective in reducing acute postoperative pain, opening the door to a new way of managing short-term pain that avoids the pitfalls...
