by American Chemical Society Credit: Pixabay/CC0 Public Domain Just as bacteria can develop antibiotic resistance, viruses can also evade drug treatments. Developing therapies against these microbes is difficult because viruses often mutate or hide themselves within cells. But by mimicking the way the immune system naturally deals with invaders, researchers reporting in ACS Infectious Diseases have developed a “peptoid” antiviral...
by City of Hope National Medical Center The City of Hope-developed small molecule AOH1996 targets a cancerous variant of the protein PCNA. In its mutated form, PCNA is critical in DNA replication and repair of all expanding tumors. Here we see untreated cancer cells (left) and cancer cells treated with AOH1996 (right) undergoing programmed cell death...
by Chinese Academy of Sciences Strategy of using photothermal nanoparticle-based whole tumor cell vaccine (LN-TCV) for on-demand near-infrared (NIR) manipulation of immune responses against cancer. Credit: MENG Jiaqi Based on non-invasive, easy-to-manipulate near-infrared (NIR) laser irradiation, researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences and the University of the Chinese Academy of...
by Anna Zarra Aldrich, University of Connecticut Proper regulation of LRRK2 levels is important for Parkinson’s disease (PD). ATIC, a purine biosynthesis pathway enzyme, and its substrate precursor AICAr regulate LRRK2 mRNA levels via an mRNA decay pathway. AICAr suppresses LRRK2 expression and can rescue LRRK2-induced dopaminergic neurodegeneration and neuroinflammation in PD animal models. Credit: The EMBO...
by McMaster University LFD based on EPX aptamer. A) Schematic illustration of structure switching construct and anticipated positive and negative tests in the presence and in absence of EPX. B) Sequences used to produce the aptamer-based LFD. C) LFD images obtained from positive and negative patient sputum samples without added SDS. NC: negative control (buffer alone),...
Scientists have unraveled the step-by-step activation process of a protein with a deep evolutionary history in all domains of life, opening the door to harnessing its functions for use as a biotechnology tool. The protein belongs to the “superfamily” of Argonaute proteins, which previous research has suggested to be involved in gene silencing, a fundamental process known as RNA interference....
by Justin Jackson , Medical Xpress Conversion of BCL6 auto-inhibitory pathway to feedforward loop. Credit: Nature (2023). DOI: 10.1038/s41586-023-06348-2 Scientists at Stanford University have found a way to induce cell death in cancer cells with a method that could be effective in around 50% of cancers. In a paper, “Rewiring cancer drivers to activate apoptosis,” published in Nature,...
by Chen Na, Chinese Academy of Sciences The intracellular mechanisms that support Rutin to function as a novel senomorphic agent in antiaging interventions. Credit: Dr. SUN’s group Since the discovery of hallmark features of senescence such as cell cycle arrest, apoptosis resistance and development of a senescence-associated secretory phenotype (SASP), efforts in understanding how senescent cells...
cby Suzanne Leigh, University of California, San Francisco Credit: Pixabay/CC0 Public Domain An experimental method developed to detect nerve injury in multiple sclerosis (MS) in adults also works for children with MS and other neurological conditions, even when they are symptom-free, according to an international team of researchers. In MS, early intervention with more recently approved...
by Institute of Cancer Research Kaposi sarcoma (cropped image). Credit: Yale Rosen, CC BY-SA 2.0 Scientists have unveiled the first and largest encyclopedia of protein alterations in soft tissue sarcomas—opening the door to a new era of understanding and treatment for this group of rare cancers, which account for around 4,000 cases in the U.K. each year. The...
