Tinker Ready July 24, 2023 Editor’s note: Find the latest long COVID news and guidance in Medscape’s Long COVID Resource Center. Doctors who treat patients with long COVID, hampered by a lack of federally approved treatments, are turning to off-label use of drugs designed for addiction, diabetes, and other conditions. Those with long COVID for years now are engaging in...
Month: <span>August 2023</span>
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How Dangerous Are Soccer Concussions? They May Cause Lasting Damage
By Lauren J. Young on July 18, 2023 Briana Scurry photographed in her Mount Pleasant apartment in Washington, D.C. on October 15, 2013. She’s lived with chronic headaches for three years due to a concussion in 2010. Credit: Marvin Joseph/The Washington Post via Getty Images An epic clash in women’s soccer starts Thursday in Australia and New Zealand as...
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FDA Approves Quizartinib for Newly Diagnosed AML
M. Alexander Otto, PA, MMS July 20, 2023 The US Food and Drug Administration today approved quizartinib (Vanflyta) for adults with acute myeloid leukemia (AML) that carries the FLT3-ITD genetic mutation. The FDA also approved the LeukoStrat CDx FLT3 Mutation Assay to determine whether patients have this mutation. The agency granted quizartinib a first-line indication for use in combination with standard chemotherapy — cytarabine and...
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T3 in Hypothyroidism Gets Extra Recommendation, With Caveats
Nancy A. Melville July 20, 2023 New recommendations from the Joint British Thyroid Association/Society add to the increasingly general consensus that liothyronine (LT3) may be useful in combination with standard levothyroxine (LT4) in the treatment of hypothyroidism in some patients whose symptoms persist after standard treatment, despite a lack of evidence of benefit in clinical trials. “Most patients with primary hypothyroidism respond well to levothyroxine replacement...
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Researchers Locate Signals in Brain Related to Chronic Pain
Jay Croft May 24, 2023 Using surgical implants inside the brain, scientists have recorded for the first time electrical patterns that occur when a person is feeling chronic pain, a new study in Nature Neuroscience concludes. The researchers used the devices on four patients who had felt endless nerve pain for more than a year. The devices recorded several times a...
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Researchers find an epigenetic key that unlocks common deadly cancers
by Katherine Fenz, Rockefeller University Lesions (in green) akin to basal cell carcinoma that were induced by SOX9 in the epidermis. Abnormal differentiation is shown in red, and blue marks cell nuclei. Credit: Yihao Yang, Fuchs Lab Early on, every stem cell faces a fateful choice. During skin development, for instance, the embryonic epidermis begins as...
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Could GLP-1 Receptor Agonists Ease Knee Osteoarthritis Pain, Slow Progression?
Marlene Busko July 24, 2023 Could glucagon-like peptide-1 receptor agonists, such as liraglutide and semaglutide, also be potential disease-modifying treatments for knee osteoarthritis (KOA)? Weight loss is recommended for patients with KOA, and GLP-1 receptor agonists are approved for weight loss. New early research suggests these drugs might have a disease-modifying effect for KOA. Three recently published studies investigated this: The LOSEIT phase 4, randomized controlled...
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Researchers identify a potential therapeutic target against cirrhosis and liver inflammation
UNIVERSITY OF BARCELONA The RNF41 protein could be a new therapeutic target in the fight against two chronic liver diseases: cirrhosis and liver inflammation. This is stated in a study published in the journal Science Translational Medicine led by researcher Pedro Melgar-Lesmes, from the Department of Biomedicine at the Faculty of Medicine and Health Sciences of the...
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Alternative cellular ‘fuels’ boost immunity
VAN ANDEL RESEARCH INSTITUTE IMAGE: DR. RUSSELL JONES, VAN ANDEL INSTITUTE CREDIT: COURTESY OF VAN ANDEL INSTITUTE GRAND RAPIDS, Mich. (July 28, 2023) — A metabolic by-product that is more prevalent during fasting may supercharge immune cells as they fight infection and disease, reports an early stage study by Van Andel Institute scientists and collaborators. The findings, published today in Immunity,...
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Newly-discovered antibodies can neutralize COVID-19 variants, potentially prevent future coronavirus outbreaks
by Federico Graciano, Duke-NUS Medical School A colorized scanning electron micrograph of the SARS-CoV-2 virus. Credit: NIAID Exceptionally potent antibodies that can neutralize virtually all known variants of the COVID-19 virus—including omicron, as well as other dangerous animal coronaviruses that could potentially cause future outbreaks—have been discovered in a new study just published in Science Advances. The...