Joshua J. Neumiller, PharmD, CDCES; Radica Z. Alicic, MD, MSc Initially approved by the US Food and Drug Administration (FDA) in 1994, metformin has been the preferred first-line glucose-lowering agent for patients with type 2 diabetes (T2D) owing to its effectiveness, low hypoglycemia risk, weight neutrality, long clinical track record of safety, and affordability. However,...
Month: <span>September 2023</span>
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Trends in suicide rates among post-9/11 veterans with and without traumatic brain injury
JAMA NETWORK About The Study: In a large cohort of U.S. military veterans serving after 9/11, suicide rates increased more than 10-fold from 2006-2020, a significantly greater rate of change than in the U.S. adult population. Over the 15-year period, veterans with traumatic brain injury (TBI) had suicide rates 56% higher than veterans without TBI...
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Could a Malpractice Insurer Drop You When You Need It Most?
Ann W. Latner, JD August 21, 2023You’ve practiced medicine for years without issues, but now you are facing a medical malpractice case. No worries — you’ve had professional liability insurance all this time, so surely there’s nothing to be concerned about. Undoubtedly, your medical malpractice insurer will cover the costs of defending you. Or will...
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My Favorite Iron Pearls
Douglas S. Paauw, MD A 45-year-old women presents for evaluation of fatigue. She has been tired for the past 6 months. She has had no problems with sleep and no other new symptoms. Her physical exam is unremarkable. Her Patient Health Questionnaire–9 score is 4. Lab results are as follows: hemoglobin, 13 g/dL; hematocrit, 39%;...
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Alternatives to indwelling urinary catheters help patients avoid infections and urethral trauma
by Society for Healthcare Epidemiology of America Alternatives to indwelling urinary catheters help patients avoid infections and urethral traumaAvoiding the unnecessary use of indwelling catheters and promptly removing catheters that are no longer needed are the first steps in preventing catheter-associated urinary tract infections in acute care hospitals, according to new recommendations. The model, “Disrupting...
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Many older adults want RSV vaccine, poll shows
by University of Michigan Many older adults want RSV vaccine, poll showsKey findings from the National Poll on Healthy Aging poll of adults age 60 to 80 about their awareness of, and interest in getting, the first vaccine against respiratory syncytial virus or RSV. Credit: University of MichiganThe first Americans over age 60 just started...
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The key to depression, obesity, alcoholism – and more? Why the vagus nerve is so exciting to scientists
Linda Geddes I’ve made a cup of coffee, written my to-do list and now I’m wiring up my ear to a device that will send an electrical message to my brainstem. If the testimonials are to believed, incorporating this stimulating habit into my daily routine could help to reduce stress and anxiety, curb inflammation and...
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U of M research team successfully tests new antifungal therapy for fungal meningitis
UNIVERSITY OF MINNESOTA MEDICAL SCHOOL MINNEAPOLIS/ST. PAUL (08/22/2023) —A team of University of Minnesota Medical School researchers successfully tested a new antifungal therapy to treat fungal meningitis. The trial results were published today in the peer-reviewed journal Clinical Infectious Diseases. The research team tested a new oral formulation of the antifungal medication amphotericin among people...
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Protein score, from a single plasma sample, predicts atherosclerotic cardiovascular disease
DECODE GENETICS IMAGE: KARI STEFANSSON CEO OF DECODE GENETICS AND AUTHOR ON THE PAPER WITH HANNES HELGASON SCIENTIST AT DECODE GENETICS AND AUTHOR ON THE PAPER. view more CREDIT: DECODE GENETICS In a large retrospective analysis using measurements of thousands of plasma proteins in primary and secondary event populations, scientists from deCODE genetics a subsidiary...
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Study shows timing is key in cortisone treatment of inflammation
by Ute Schönfelder, Friedrich-Schiller-Universität Jena Dexamethasone (Dex) impacts LM biosynthetic pathways during M1 and M2 polarization in a concentration-dependent manner. (A, B, C) Human monocytes-derived macrophages (MDM, 2 × 106 cells/ml) were preincubated with Dex at different concentrations as indicated (Dex, blue) or vehicle (0.1% DMSO, black) for 15 min and were then polarized for...