by Krishna Ramanujan, Cornell University Associative and predictive codes in the hippocampus. Our optogenetic manipulation perturbed hippocampal sequences without affecting cell coactivity, thus selectively disrupting the predictive code. After learning, cell assemblies were reactivated, but their order was not preserved, abolishing sequential replay (right). Perturbing the predictive code had no effect on associative learning (bottom left)...
Diagnosing atherosclerosis with an oxidative stress biomarker triggered multiplexed instrument
by Thamarasee Jeewandara , Medical Xpress A multiplexed diagnostic tool for detecting intraplaque and urinary MDA. We design a multiplexed diagnostic tool that includes two functions (photoacoustic imaging and urinalysis), for assessing intraplaque and urinary MDA and reliably assessing intraplaque and systematic oxidative stress in atherosclerosis. Credit: Science Advances, DOI: 10.1126/sciadv.adh1037Oxidative stress is fundamental to...
New large-scale study results add to evidence that vestibular loss increases dementia risk
by Stephanie Baum , Medical Xpress The relationship between vestibular loss and the risk of dementia. Credit: Scientific Reports (2023). DOI: 10.1038/s41598-023-42598-wExisting research shows a link between hearing loss and the risk of dementia, and a new study adds to growing evidence that vestibular loss can increase dementia risk as well. Results from this work,...
CDC estimates 220,000 in US under 18 diagnosed with arthritis
David Goldman, File/AP A sign marks the entrance to the federal Centers for Disease Control and Prevention. (David Goldman, File/AP)An estimated 220,000 children and adolescents in the United States have been diagnosed with arthritis, according to new research from the Centers for Disease Control and Prevention (CDC). While arthritis is most often associated with older...
Respiratory virus season threatens to be a challenge again. Getting vaccinated now can help
Deidre McPhillips, CNN Mon, October 23, 2023 at 3:29 AM MST Francine Orr/Los Angeles Times/Getty ImagesThe first signs of respiratory virus season are just starting to show in the United States, but experts stress the importance of getting vaccinated now to stay healthy through the winter and reduce strain on the health care system. Forecasts...
Here are which COVID symptoms to look out for this fall
By Matt Stefanski and NBC Chicago Staff • Published October 23, 2023 • Updated on October 23, 2023 at 3:48 pmEven though COVID positivity rates and hospitalizations have declined in recent weeks, for many concerns persist about becoming ill this fall, a time of the year that typically sees a surge in COVID, influenza and...
‘Extremely rare’ case of mosquito-borne dengue found in California
A California health department has confirmed its first locally-acquired case of dengue virus in one of its residents. Alex ArgerPosted: 6:22 p.m. EDT Oct 23, 2023An “extremely rare” illness completely foreign to the state of California has been discovered there, and its appearance is not associated with travel. On Friday, officials with the health department...
We can’t defeat cancer without acknowledging the differences between men and women, say scientists
by Isy Godfrey, Institute of Cancer Research The complex tumour immune microenvironment in patient samples of muscle-invasive bladder cancer, captured using develop a new multiplex immunofluorescence panel. Credit: Integrative Pathology Unit at The ICR and The Royal Marsden NHS Foundation TrustFor generations, the medical community has used the “standard human”—a 70-kilogram male—to guide education, research and...
Blood test detects tumors early in families with Li-Fraumeni syndrome
by The Hospital for Sick Children Credit: CC0 Public DomainResearchers from The Hospital for Sick Children (SickKids), the Ontario Institute for Cancer Research (OICR) and University Health Network (UHN) have demonstrated that by analyzing patients’ blood samples, they are able to detect cancer earlier in individuals with Li-Fraumeni syndrome, an inherited condition with an almost 100%...
Study shows the microbiome of fruit and vegetables positively influences diversity in the gut
by Falko Schoklitsch, Graz University of Technology Overview of the bioinformatic workflow for the recovery of metagenome-assembled genomes (MAGs) from fruits and vegetables and the detection of their presence in the gut. Credit: Gut Microbes (2023). DOI: 10.1080/19490976.2023.2258565Bacterial diversity in the gut plays an important role in human health. The crucial question, however, is where are...