MONELL CHEMICAL SENSES CENTER PHILADELPHIA (August 24, 2023) – A bitter taste in the mouth is often a symptom or side effect of illness, which may be the result of how the body reacts to pathogens. A new study published in iScience, by Hong Wang, PhD, an Associate Member at the Monell Chemical Sense Center,...
Month: <span>October 2023</span>
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Common supplements might reduce natural hearing loss
PLOS IMAGE: PRESTIN EXPRESSION IN OHCS FROM CONTROL, EFAVIRENZ, AND EFAVIRENZ PLUS PHYTOSTEROLS-TREATED MICE. CREDIT: SODERO AO ET AL., 2023, PLOS BIOLOGY, CC-BY 4.0 (HTTPS://CREATIVECOMMONS.ORG/LICENSES/BY/4.0/) Researchers led by María Eugenia Gomez-Casati, the Institute of Pharmacology, School of Medicine, University of Buenos Aires-CONICET; Mauricio Martin, the Institute of Medical Research Mercedes; and Martín Ferreyra, (INIMEC-CONICET-UNC), National...
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Scientists discover a previously unknown way cells break down proteins
HARVARD MEDICAL SCHOOL At a glance: Scientists have discovered a previously unknown mechanism by which cells break down proteins that are no longer needed.These proteins are short-lived and modulate genes that support important neural, immune, and developmental processes.The mechanism could inform the design of therapies to treat conditions that arise when cells make too much...
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New pocket-sized device for clinicians could spot infected wounds faster
by Frontiers Credit: Unsplash/CC0 Public DomainIt’s notoriously difficult for doctors to identify a wound that is becoming infected. Clinical signs and symptoms are imprecise and methods of identifying bacteria can be time-consuming and inaccessible, so a diagnosis can be subjective and dependent on clinician experience. But infection can stall healing or spread into the body...
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Women more severely affected by ME/CFS, study shows
by University of Edinburgh Credit: Unsplash/CC0 Public Domain Women with ME/CFS tend to have more symptoms and co-occurring conditions than men, according to initial results from the world’s largest study of the disease. It has long been known that women are more likely to have ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome) but the DecodeME study has...
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Gene editing system restores dystrophin function in stem cells from patients with Duchenne muscular dystrophy
by Cell Press This photo shows green dystrophin protein restored by dual-Cas3 in skeletal muscle derived from DMD patient iPSCs. Credit: Akitsu HottaDuchenne muscular dystrophy (DMD) is a muscle degeneration disorder caused by mutations affecting the dystrophin gene. On August 24 in the journal Stem Cell Reports, researchers show how a dual CRISPR RNA method...
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Could physical activity help lower the risk of AFib and stroke?
Being more physically active could help lower the risk of experiencing a range of cardiovascular events. Antonio_Diaz/Getty Images Atrial fibrillation (AFib) is an abnormal heart rhythm that can harm cardiovascular health.Study findings presented at the ESC Congress 2023 found that higher levels of physical fitness were associated with decreased risk for atrial fibrillation, stroke, and...
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Unraveling the mechanism behind obesity-induced pancreatic β-cell dysfunction
by University of Tsukuba Credit: Cell Reports (2023). DOI: 10.1016/j.celrep.2023.112914 Obesity not only increases the risk of metabolic syndrome-related diseases, such as diabetes, fatty liver, and atherosclerosis, but also remarkably impacts seemingly unrelated conditions, such as cancer, psychiatric disorders, and immune function. To understand this wide range of diseases and develop therapeutic approaches for the...
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Researchers discover novel approach for rebuilding, regenerating lung cells
by Boston University School of Medicine Credit: Pixabay/CC0 Public DomainResearchers from the Center for Regenerative Medicine (CReM), a joint venture between Boston University and Boston Medical Center, have discovered a novel approach for engrafting engineered cells into injured lung tissue. These findings may lead to new ways for treating lung diseases, such as emphysema, pulmonary...
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Expression pattern of key receptors in the hypothalamus revealed
by Susann-C. Ruprecht, Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke Brain slices of the mouse are placed onto a glass slide, for further imaging. Credit: David AusserhoferThere is growing evidence that peptide hormones from the gut have far-reaching effects on the whole organism. By binding to corresponding receptors in the brain, they can modulate food intake and...