by University of Texas Health Science Center at San Antonio Credit: Pixabay/CC0 Public DomainUrine levels of adenine, a metabolite produced in the kidney, are predictive and a causative biomarker of looming progressive kidney failure in patients with diabetes, a finding that could lead to earlier diagnosis and intervention, researchers from The University of Texas Health...
by Van Andel Research Institute SNc DA degeneration induces cell subtype–and input-specific alterations in M1.(A) Overall strategies to label projection defined M1 pyramidal neurons and optogentically activate thalamocortical transmission arising from the mTh. (B) Overlaid image showing the averaged AAV injection sites in the motor thalamus (left), as well as representative confocal images showing an...
by Texas Children’s Hospital The molecular regulation of Wnt signaling in the OL lineage by Daam2 phosphorylation. The activity of Daam2-mediated Wnt signaling is low in OPCs and early OLs (Left) but upregulated in mature OLs (Middle). When ligands trigger Wnt signaling, the destruction complex is inhibited, allowing β-catenin to enter the nucleus where it...
October 16, 20235:01 AM ET Jon Hamilton Scientists are one step closer to understanding the 170 billion brain cells that allow us to walk, talk, and think. A newly published atlas offers the most detailed maps yet of the location, structure, and, in some cases, function of more than 3,000 types of brain cells. “We...
Ability to reverse cancer’s resistance to therapy opens possibility of treatment for late-diagnosed men Andrew Gregory Health editor Scientists say a new way to treat prostate cancer may be on the horizon after finding it is possible to reverse its resistance to therapy. More than a million men worldwide are diagnosed with the disease each year....
by Homa Warren, Baylor College of Medicine Graphical abstract. Credit: Cell Reports (2023). DOI: 10.1016/j.celrep.2023.113240Previous research has implicated fungi in chronic neurodegenerative conditions such as Alzheimer’s disease, but there is limited understanding of how these common microbes could be involved in the development of these conditions. Working with animal models, researchers at Baylor College of Medicine...
by Molly Chiu, Baylor College of Medicine Plasma metabolites in historic controls versus recipients of RPS. a, UMAP ordination of median-centered plasma metabolite levels revealed four distinct clusters of metabolites. b, UMAP ordination stratified according to clinical group (historic controls in blue or recipients of RPS in orange), with the largest divergence in overlap at engraftment....
by University of Montreal Credit: Pixabay/CC0 Public DomainCanadian scientists have found a new link between two major metabolic diseases: diabetes and steatotic liver disease, commonly known as fatty liver disease. Published in Diabetes, research into the two diseases by Université de Montréal medical professor Jennifer Estall and her team at the Montreal Clinical Research Institute (IRCM)...
by NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development Credit: PLOS Computational Biology (2023). DOI: 10.1371/journal.pcbi.1011462A research team has developed a smart phone app that can track and analyze a person’s ability to move from one place to another, known as locomotion, and other types of movements. Human motion analysis is used to...
by Tracey Peake, North Carolina State University Credit: Unsplash/CC0 Public DomainResearchers from North Carolina State University have pinpointed a particular peptide’s role in activating atopic dermatitis, or eczema. The work could lead to more effective treatments for the condition. Atopic dermatitis (AD) is a skin condition characterized by itching, irritated and thickened skin at the site...
