OCTOBER 26TH, 2023 CONN HASTINGS DIAGNOSTICS, GENETICS Researchers at the University of Massachusetts Amherst have developed a new method of detecting very small amounts of DNA. The breakthrough could allow clinicians to spot genetic markers of disease at the point-of-care, as the approach does not require conventional laboratory analysis, which is usually time-consuming and costly. In fact, the...
Peer-Reviewed Publication THE UNIVERSITY OF BERGEN IMAGE: FIGURE 1: N-TERMINAL ACETYLATION BY NATC SHIELDS PROTEINS FROM DEGRADATION. (LEFT) THE NATC COMPLEX ACETYLATES PROTEINS HARBORING A HYDROPHOBIC RESIDUE IN THE SECOND POSITION (MΦ). FOLLOWING NT-ACETYLATION, AC-UBE2M AND AC-UBE2F PROMOTE CULLIN NEDDYLATION (N8), RESULTING IN UBIQUITYLATION (UB) AND PROTEASOMAL DEGRADATION OF TARGETED CULLIN SUBSTRATES, AC-ARFRP1 IS TARGETED...
by University College London Credit: samer daboul from PexelsA new drug candidate, based on pioneering UCL and Moorfields Eye Hospital research and currently under development by SIFI S.p.A., has been found to be highly effective in treating a rare sight-threatening eye infection in a new international clinical trial. The findings, published in Ophthalmology, describe the efficacy...
by Bar-Ilan University Credit: Pixabay/CC0 Public DomainSevere combined immunodeficiencies (SCIDs) are a group of debilitating primary immunodeficiency disorders, primarily caused by genetic mutations that disrupt T-cell development. SCID can also affect B-cell and natural killer cell function and counts. Left untreated, SCID proves fatal within the first year of life. The conventional treatment for SCID patients...
by Olivia Dimmer, Northwestern University Multiplex immunofluorescence staining and imaging using the COMET system platform on a human meningioma patient sample, showing SSTR2+ tumor cells (in red), expressing the hedgehog pathway activation marker sonic hedgehog (SHH, in cyan blue). Credit: Hinda NajemScientists have uncovered a genetic explanation for one subset of common brain tumors, according to...
by Ashley WennersHerron, Pennsylvania State University Schematic representation of two approaches based on changes in absorbance and lateral flow methods, utilizing novel oligonucleotide probes targeted toward Chlamydia trachomatis and Neisseria gonorrhoeae, for the clinical determination of chlamydia and gonorrhea. The addition of genetic material (bacterial DNA from either Chlamydia trachomatis or Neisseria gonorrhoeae) will result in...
by University of Tsukuba Researchers moved a mannequin equipped with a device that emits aerosol particles to examine the number and movement of the particles. Credit: Takeshi Asai, professor emeritus at the University of TsukubaThe main transmission routes identified initially for the novel coronavirus infection were droplet and contact transmission. Airborne transmission by aerosol particles was...
Peer-Reviewed Publication BAYLOR COLLEGE OF MEDICINE Inflammation is a risk factor for many chronic diseases, including cardiovascular disease (CVD), and the impact of diet on inflammation is an area of growing scientific interest. In particular, recommendations to limit red meat consumption are often based, in part, on old studies suggesting that red meat negatively affects...
by Zachary Sweger, Pennsylvania State University Penn State College of Medicine researchers are studying how cannabinoids may manage pain and promote bone healing in bone fractures. Fluorescence microscopy reveals how periosteal bone progenitors, which later develop into specialized bone cells that help bone tissue for, appear in healing tissue. Credit: Reyad Elbarbary/Penn StateCannabidiol (CBD) and cannabigerol...
by University of Copenhagen Credit: CC0 Public DomainArtificial intelligence can help health care systems under pressure allocate limited resources, but also lead to more unequal access. This is demonstrated by a research collaboration between the University of Copenhagen, Rigshospitalet and DTU that investigated whether AI can spot the risk of depression equally across different population segments....
