by Cedars-Sinai Medical Center Correlations among abundance levels of 12 species associated with insulin homeostasis traits or dysglycemia. Correlation coefficients are displayed, with shades of red representing positive values and shades of blue representing negative values. The two clusters of species are outlined with squares. *P < 0.05 and >0.01; **P < 0.01 and ≥0.0001;...
by Harrison Tasoff, University of California – Santa Barbara Under the previous model (top), an odor would activate an increasing number of olfactory sensory neurons as it’s concentration rose. The new findings (bottom) showed that the activity of the most sensitive neurons fell off as others joined. Credit: TADRES ET AL. The delicate fragrance of...
UNIVERSITY OF CALIFORNIA – SANTA BARBARA IMAGE: ZEBRAFISH EMBRYO CREDIT: UC SANTA BARBARA Building tissues and organs is one of the most complex and important tasks that cells must accomplish during embryogenesis. Individual cells do not make these decisions; rather, building tissue is a collective task that requires cells to constantly communicate with each other....
SOCIETY OF NUCLEAR MEDICINE AND MOLECULAR IMAGING IMAGE: THIS FIGURE HIGHLIGHTS 3 PATIENTS WITH A FINAL DIAGNOSIS OF LOW-GRADE UPTAKE (PERUGINI GRADE-1). ENDOMYOCARDIAL BIOPSY RESULTS WERE AVAILABLE FOR THE PATIENT DEPICTED IN PANEL B DEMONSTRATING ATTR-CA AS THE UNDERLYING PATHOLOGY. CREDIT: IMAGE CREATED BY DEPARTMENT OF NUCLEAR MEDICINE, MEDICAL UNIVERSITY OF VIENNA, AUSTRIA. Reston, VA—A...
BOSTON CHILDREN’S HOSPITAL Neurofibromatosis type 1 (NF1) is a common genetic condition, affecting 1 in 3000 individuals, and people with NF1 are at greater risk of developing a rare, aggressive form of cancer. Diagnosing malignant peripheral nerve sheath tumors (MPNSTs) often comes too late, after the cancer has spread and is difficult to treat. But...
SALK INSTITUTE IMAGE: TIME-RESTRICTED EATING RESHAPES GENE EXPRESSION THROUGHOUT THE BODY. IN THIS ILLUSTRATION, THE FERRIS WHEEL DISPLAYS THE INTERCONNECTED ORGAN SYSTEMS WORKING SMOOTHLY DURING TIME-RESTRICTED EATING, WHICH IS REPRESENTED BY THE CLOCK IN THE MIDDLE. CREDIT: SALK INSTITUTE LA JOLLA (January 3, 2023)— Numerous studies have shown health benefits of time-restricted eating including increase...
by Massachusetts Institute of Technology A figure from the paper depicts pathways perturbed in Alzheimer’s disease. Examples are listed for each pathway by major brain cell type. Credit: Tsai Lab/MIT Picower Institute After decades of fundamental scientific and drug discovery research, Alzheimer’s disease has remained inscrutable and incurable, with a bare minimum of therapeutic progress. But...
by Salk Institute Graphical abstract. Credit: Cell Metabolism (2023). DOI: 10.1016/j.cmet.2022.12.004 Obesity and metabolic diseases, such as diabetes, are extremely common in the United States. Tiny proteins called microproteins have long been overlooked in research, but new evidence demonstrates that they have an important role in metabolism. Salk scientists have discovered that both brown and white fat is...
by Tracey Peake, North Carolina State University Linoleic acid (LA) metabolites are found in both the free and total pools of fatty acids in human skin. A box represents the schematic depiction of a) LA or oxylipins (i.e., 9,13-EHL and 9,10,13-THL) derived from LA are esterified into lipid membranes. b) Hydrolysis by enzymes such as...
by University of Manchester A) Published reports of histoplasmosis by state of residence of patients. B) Published reports of histoplasmosis according the authors’ institution, by state. Credit: Open Forum Infectious Diseases (2022). DOI: 10.1093/ofid/ofac603 Researchers from India and Manchester have shown that over fifty million Indians are affected by serious fungal disease, 10% of which are from potentially...
