by Holly Evarts, Columbia University School of Engineering and Applied Science Fluorescence microscopy image of lung cancer cells stained with antibodies against proteins involved in cellular growth. Credit: Dhruba Deb/Columbia Engineering Lung cancer is the deadliest cancer in the United States and around the world. Many of the currently available therapies have been ineffective, leaving...
By Michael Irving December 22, 2022 Scientists have created stem cells that are genetically identical except for their sex chromosomes, paving the way for a powerful platform for studying sex differences in biology and medicineDepositphotos Scientists in Israel have for the first time created male and female stem cells from the same person. This breakthrough...
by Valerie Goodwin, University of Michigan Associations between patient-reported outcomes for physical function, cognitive function, and pain intensity (n = 130 for A and C; n = 139 for B). Pearson r and associated P values are indicated. aPL, antiphospholipid antibodies; APS, antiphospholipid syndrome. Credit: ACR Open Rheumatology (2022). DOI: 10.1002/acr2.11512 Antiphospholipid syndrome is an autoimmune disease that preferentially affects women. Patients with APS are...
by Michael Mathai, The Conversation Like the slogan on the bottle says: ‘I put Sriracha on my Sriracha’. Credit: Unsplash/Hiroko Nishimura, CC BY The news of a hot chili sauce shortages earlier this year—due to high temperatures and drought in agricultural regions—prompted warnings to stock up on supplies or forego adding this flavor to your food. But what prompts...
by Delthia Ricks, Medical Xpress TCS2 protein reduction in SMA-positive areas in small PAs from SM22-Tsc+/- mice. a: SM22-Cre mice were bred with Tsc2flox/flox mice to generate SM22-Tsc+/- mice. b: Immunohistochemical analysis of lung tissue sections of SM22-Tsc2+/- mice to detect TSC2 (red), smooth muscle α-actin (SMA) (green), and DAPI (blue). Representative images from n=5 WT and 7 SM22-Tsc2+/- mice...
by Agency for Science, Technology and Research (A*STAR), Singapore Graphical abstract. Credit: Theranostics (2022). DOI: 10.7150/thno.72947A recent study discovered a novel therapeutic target named ADAM10 that could be used to treat patients with Diabetic Retinopathy (DR), a condition that leads to blindness induced by prolonged diabetes. Abnormal blood vessel formation in the eyes of diabetic patients is...
by King’s College London Credit: Pixabay/CC0 Public Domain In a study examining the link between non-alcoholic fatty liver disease (NAFLD) and brain dysfunction, scientists at the Roger Williams Institute of Hepatology, affiliated to King’s College London and the University of Lausanne, found an accumulation of fat in the liver causes a decrease in oxygen to...
by Charité – Universitätsmedizin Berlin Fluorescence microscope image of cells in the lung’s blood vessels. The study has shown for the first time that these cells possess a CFTR chloride channel (green), and that lung inflammation-induced loss of this channel results in increased permeability of pulmonary vessels. Cell nuclei appear as round dark spots, and cell...
by University of Tsukuba Credit: Christoph Burgstedt/Shutterstock Vascular diseases such as atherosclerosis, pulmonary hypertension, and cardiac fibrosis are associated with a reorganization of the structure of blood vessels. Researchers led by the University of Tsukuba have demonstrated transdifferentiation, an important process by which this reorganization occurs that holds promise for future treatments for vascular diseases. Blood vessels are...
by Helmholtz Association of German Research Centres Stem cell–derived beta cell cluster. Credit: Chenglei Tian & Henrik Semb In order to treat patients with diabetes in the best possible way it is necessary to understand the disease mechanism. MODY type 3 (MODY3) is a monogenic hereditary form of diabetes that is caused by a genetic defect in the...
