By Kelsey Ables; December 22, 2022 at 5:45 a.m. EST Persistent loss of smell has left some covid-19 survivors yearning for the scent of their freshly bathed child or a waft of their once-favorite meal. It’s left others inured to the stink of garbage and accidentally drinking spoiled milk. “Anosmia,” as experts call it, is one...
Year: <span>2023</span>
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Scientists produce eye tissue using 3D printing and stem cells – their work could lead to breakthrough treatments for age-related macular degeneration that impacts 20M Americans
By CHRISTOPHER CARBONE, U.S. SCIENCE AND TECHNOLOGY EDITOR FOR DAILYMAIL.COM Scientists have figured out a way to create eye tissue using stem cells and 3D printing – in new research that could lead to breakthroughs in treating a range of degenerative eye diseases. A team of researchers from the National Eye Institute (NEI), part of the National Institutes of...
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Study links metabolism changes in certain brain cells to Huntington’s disease
by Pat Harriman, University of California, Irvine Single nucleus RNAseq of mouse and human R6/2 and HD samples. a Illustration of workflow used for this study. After frozen tissue is microdissected from the Cingulate, Caudate, and nucleus Accumbens from 66 samples from 29 human donors (3 grade I, 4 grade II, 4 grade III, 3 grade IV, 5...
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New drug offers hope for people with hand osteoarthritis
by University of Oxford Diagram illustrating the anti-inflammatory role of all-trans retinoic acid (atRA) after cartilage injury. Credit: Science Translational Medicine (2022). DOI: 10.1126/scitranslmed.abm4054 A new study, published in Science Translational Medicine by researchers at the University of Oxford has identified that Talarozole, a drug that is known to increase retinoic acid, was able to prevent osteoarthritis (OA) in disease models. Tonia...
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How fat takes over the lymph nodes as we age
by Linda Koffmar, The Swedish Research Council Co-expression of fibroblast and adipocyte markers suggest lipomatosis is driven by adipogenic transdifferentiation of medullary fibroblasts. Immunofluorescence staining of lymph nodes (LNs) with lipomatosis. (A) Presence of adipocytes (perilipin, magenta) and fibroblasts (alpha smooth muscle actin; αSMA, green) in medullary cords. Arrowheads indicate adipocytes present in the layer of medullary...
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Study traces shared and unique cellular hallmarks found in 6 neurodegenerative diseases
by Arizona State University The illustration shows the cell types and brain regions affected by six different neurodegenerative diseases: Friedreich’s ataxia (purple); Huntington’s disease (blue); frontotemporal dementia (yellow); amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND) or Lou Gehrig’s disease (green); Parkinson’s disease (orange); and Alzheimer’s disease (pink). Credit: Shireen Dooling A perplexing...
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Scientists find key reason why loss of smell occurs in long COVID-19
by Duke University Medical Center Credit: Unsplash/CC0 Public Domain The reason some people fail to recover their sense of smell after COVID-19 is linked to an ongoing immune assault on olfactory nerve cells and an associated decline in the number of those cells, a team of scientists led by Duke Health report. The finding, publishing online...
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Infant gene therapy is a breakthrough for Artemis-SCID patients
by University of California, San Francisco Credit: CC0 Public Domain Ten young children born without functioning immune systems and lacking the ability to fight infections are on track for healthier lives thanks to a new gene therapy treatment pioneered at UC San Francisco, reports a Dec. 22 study in the New England Journal of Medicine. The children...
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Gene therapy corrects mutation responsible for common heart condition, research shows
by UT Southwestern Medical Center These representative hearts from 12-week-old mice show a normal heart (left) and an enlarged heart that’s characteristic of dilated cardiomyopathy. Credit: UT Southwestern Medical Center Using the CRISPR-Cas9 gene editing system, UT Southwestern researchers corrected mutations responsible for a common inherited heart condition called dilated cardiomyopathy (DCM) in human cells and a mouse...
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How nerve and vascular cells coordinate their growth
by University of Bonn Blood vessels (red) migrate in a disorganized manner to regions with motor neurons (green). Credit: AG Ruiz de Almodovar/University of Bonn Nerve cells need a lot of energy and oxygen. They receive both through the blood. This is why nerve tissue is usually crisscrossed by a large number of blood vessels. But...