by Elana Gotkine For patients with moderate-to-severe plaque psoriasis, the interleukin-23-receptor antagonist peptide JNJ-77242113 shows greater efficacy than placebo, according to a study published in the Feb. 8 issue of the New England Journal of Medicine. Robert Bissonnette, M.D., from Innovaderm Research in Montreal, and colleagues conducted a phase 2 dose-finding trial involving 255 patients...
Month: <span>February 2024</span>
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Q&A: Should heart patients consider taking weight loss medications?
by Noah Fromson, University of Michigan Credit: Unsplash/CC0 Public DomainOver the last year, prescriptions for medications that can accelerate weight loss in people with diabetes or without it have skyrocketed. Known by brand names like Ozempic and Wegovy, the drugs have gotten a lot of attention for their cost, their potential impact on weight, and their...
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New PET tracer detects inflammatory arthritis before symptoms appear
by Society of Nuclear Medicine and Molecular Imaging A) PET images of [68Ga]Ga-DOTA-ZCAM241 uptake at baseline and 3, 7, and 12 days after injection as inflammatory arthritis developed in single representative individual mouse. Images are normalized to SUV of 0.5 for direct comparison between time points. (B) CD69 immunofluorescence Sytox (Thermo Fisher Scientific) staining of...
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Scientists gain new insights into how small intestine works
by Ernie Mundell It was the ancient Greeks who first divided the 20-foot length of the small intestine into three parts: The duodenum, the jejunum and the ileum. However, the organ may finally be ready for an update: U.S. researchers say the small intestine is actually comprised of five distinct segments, each being responsible for...
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Higher-dose naloxone spray didn’t save more lives, researchers find
by Mike Stobbe This image provided by Hikma Pharmaceuticals shows the company’s nasal spray drug Kloxxado, containing 8 milligrams of naloxone. A study published Thursday, Feb. 8, 2024 finds that a new, higher-dose nasal spray for reversing opioid overdoses didn’t save more lives than the standard dose. However, it was tied to more vomiting and...
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A common medication could save half a million children with diarrhea each year: Why is it underprescribed?
by Nina Raffio, University of Southern California Provider perceptions that patients do not want ORS are the most important barrier to ORS prescribing. The figure shows that if all patients showed a preference for ORS, it would increase ORS prescribing by 24.5 percentage points, from 42 to 66.5%. Thus, provider perceptions of patient preferences explain 42%...
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New study reveals mechanism of cell death in melanoma cells by cannabis extract
by Charles Darwin University Graphical abstract. Credit: Cells (2024). DOI: 10.3390/cells13030268A cannabis extract has shown positive results in slowing down melanoma cell growth and increasing cell death rates, a new in-vitro study finds. Researchers from Charles Darwin University (CDU) and RMIT investigated programmed cell death caused by a specific cannabis extract (cannabinoid PHEC-66) from the cannabis...
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Severe lung damage caused when flu is followed by infection with measles-like virus, study finds
by LaTina Emerson, Georgia State University Therapeutic treatment of lethal CDV infection in ferrets. Ferrets were infected with a lethal challenge of CDV and treated with GHP-88309, ERDRP-0519, or therapeutic vaccination. a Schematic of the study design. Ferrets were infected with wild-type recCDV-5804p and monitored for 6 weeks. Symbols in the different boxes show clinical presentation...
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Video: What is vascular dementia?
by Alex Osiadacz, Mayo Clinic Credit: Mayo Clinic News NetworkAn estimated 55 million people are believed to be living with dementia, according to the World Health Organization. Vascular diseases contribute to approximately 25% of all diagnoses. When blood vessels are damaged or blocked, it can deprive your brain of vital oxygen and nutrients, which could lead...
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Telltale amino acid deficiencies may hold the key to new treatments for long COVID, say researchers
by Gillian Rutherford, University of Alberta Altered metabolomic profile in SARS-CoV-2 infected individuals. Credit: Frontiers in Immunology (2024). DOI: 10.3389/fimmu.2024.1341843A University of Alberta research team brings together immunologists, virologists, rheumatologists and metabolomics experts in an effort to discover exactly what is ailing the sickest long COVID patients and find treatments for them. In research recently published...