by Tsinghua University Press Directed acyclic graph demonstrating the relationship between potential risk factors of mortality due to mucormycosis. Credit: Dr. Rizwan Suliankatchi Abdulkader, Indian Council of Medical ResearchMucormycosis is a relatively rare but serious fungal infection increasingly recognized for its poor prognosis and high mortality. Due to the COVID-19 pandemic, the incidence of mucormycosis...
Month: <span>February 2024</span>
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A breast cancer drug, susceptible to resistance, can be restored to effectiveness, researchers demonstrate
by Leslie Cantu, Medical University of South Carolina Credit: Pixabay/CC0 Public Domain In a new paper published in Cancer Research, researchers at MUSC Hollings Cancer Center have shown that targeting a protein called TACC3 (transforming acidic coiled-coil containing protein 3) can restore the effectiveness of the breast cancer drug T-DM1 if the cancer cells have developed...
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New technique could make human T cells 100 times more potent at killing cancer cells
by Northwestern University Credit: Pixabay/CC0 Public DomainScientists at the UC San Francisco (UCSF) and Northwestern Medicine may have found a way around the limitations of engineered T cells by borrowing a few tricks from cancer itself. By studying mutations in malignant T cells that cause lymphoma, they zeroed in on one that imparted exceptional potency to...
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The Solution to a ‘Common and Hazardous’ Symptom of Bipolar Disorder?
Recent research highlights the potential role of an atypical antipsychotic to treat anxiety, a prevalent and undertreated symptom in bipolar I disorder (BPD). Notably, investigators said, the drug comes without the typical metabolic side effects, including weight gain, associated with this drug class. A post hoc analysis of pooled data from two trials comparing two...
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New Guidelines: Start PSA Screening Earlier in Black Men
Lowering the recommended age for baseline prostate-specific antigen (PSA) would reduce prostate cancer deaths by about 30% in Black men without significantly increasing the rate of overdiagnosis, according to new screening guidelines from the Prostate Cancer Foundation. Specifically, baseline PSA testing in Black men should begin at age 40-45, sooner than current guidelines recommend, and...
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Top Causes of Early Noncancer Deaths in Advanced GU Cancers
TOPLINE:Adults diagnosed with metastatic genitourinary cancers face an increased risk for early death due to sepsis, cardiovascular disease (CVD), and other noncancer causes, new research showed. METHODOLOGY:Researchers used Surveillance, Epidemiology, and End Results data (2004-2020) to investigate noncancer causes of death in 77,246 adults with metastatic genitourinary cancers, which included bladder, kidney, and prostate cancer.The...
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Study finds patients with polycystic ovary syndrome have increased risk for suicide
by Elana Gotkine Patients with polycystic ovary syndrome (PCOS) have an increased risk for suicide, according to a study published online Feb. 6 in the Annals of Internal Medicine. Tien-Wei Hsu, M.D., from E-DA Dachang Hospital in Kaohsiung, Taiwan, and colleagues conducted a cohort study using data from the Taiwanese nationwide database from 1997 to...
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Clinician decision support can reduce unspecified testing in primary care, study suggests
by Elana Gotkine For older primary care patients, clinician decision support can reduce unspecified testing compared with traditional case-based education alone, according to a study published online Feb. 6 in the Annals of Internal Medicine. Stephen D. Persell, M.D., M.P.H., from the Northwestern University Feinberg School of Medicine in Chicago, and colleagues examined the effect...
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CDC: Biennial Surge in Acute Flaccid Myelitis Has Come to a Halt
When to expect next spike in cases is unclear, researchers sayby Katherine Kahn, Staff Writer, SA photo of a little boy who is paralyzed due to acute flaccid myelitis wearing a motorized orthotic brace.Acute flaccid myelitis (AFM) cases remained low in 2022, despite increased circulation of the enterovirus D68 (EV-D68) in the U.S., according to...
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Older Americans Are About to Lose a Lot of Weight
People over 65 make up a sizable portion of Americans on GLP-1 drugs. That might be trouble. By Daniel Engber A scale overlaid with a silhouette of an older adultIllustration by Ben Kothe / The Atlantic. Sources: Peter Dazeley; JakeOlimb / Getty.Imagine an older man goes in to see his doctor. He’s 72 years old...