JULY 24, 2024 by American Heart Association Credit: Unsplash/CC0 Public DomainIncreasing ketone supply to the heart in mice with heart failure with preserved ejection fraction (HFpEF) allowed their hearts to utilize more ketones and produce more energy, according to preliminary research presented today at the American Heart Association’s Basic Cardiovascular Sciences Scientific Sessions 2024. The...
JULY 25, 2024 by King’s College London Model of mitochondrial homeostasis and cytoplasmic viscosity during aging. Credit: Aging Cell (2024). DOI: 10.1111/acel.14250A team from King’s College London and collaborators have pinpointed how different areas of the neuron age differently, with a potential knock-on effect on healthy cell function and the development of neurodegenerative conditions. The...
JULY 25, 2024 by University of Otago Model of the oxidation-induced amyloid formation and disassembly mechanism of p16. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-49581-7Researchers from the University of Otago, Christchurch, have spearheaded the discovery of a protein function which has the potential to guide the development of novel cancer treatment options and improve the diagnosis...
JULY 25, 2024 by Jackie Maupin, Indiana University School of Medicine Design and test of split intein constructs to assemble FL-dystrophin. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-50569-6Indiana University School of Medicine researchers have made a significant breakthrough in developing a new gene therapy approach that restores full-length dystrophin protein, which could lead to new treatments...
JULY 25, 2024 by Jeff Hansen, University of Alabama at Birmingham Graphical abstract. Credit: iScience (2024). DOI: 10.1016/j.isci.2024.110395Millions of adults have atrial fibrillation—an irregular beating of the upper chambers of the heart that yields increased risk of heart failure, stroke and death. Many genetic mutations in the developing fetus can lead to adult atrial fibrillation,...
JULY 25, 2024 by Cell Press Credit: CC0 Public DomainFindings from a small, proof-of-concept clinical trial have suggested that fecal microbiota transplants (FMTs) can boost the effectiveness of immunotherapy in a range of gastrointestinal cancers. In the study, published July 25 in the journal Cell Host & Microbe, six of 13 patients who had previously...
JULY 24, 2024 by Australian National University Overview of measurement protocols used in this study, showing a 3D virtual model of the patella bone in posterior view, segmented from CT data. Measurements (inset) are numbered in ellipses as follows: 1) lateral facet area, 2) medial facet area, 3) maximum mediolateral width of the lateral facet,...
JULY 24, 2024 by University of Geneva Credit: Unsplash/CC0 Public DomainAcute myeloid leukemia (AML) is the most common blood and bone marrow cancer in adults. Caused by an increase in immature cells that rapidly destroy and replace healthy blood cells (red and white blood cells and platelets), AML is lethal in half of those affected...
JULY 24, 2024 by George Mason University Development of the SIV Rev-dependent vectors to target SIV reservoirs. Credit: Gene Therapy (2024). DOI: 10.1038/s41434-024-00467-9Researchers in George Mason University’s Center for Infectious Disease Research (CIDR) and Tulane National Primate Research Center have conducted a breakthrough proof-of-concept study, published in the journal Gene Therapy, that found an HIV-like...
JULY 23, 2024 by Karen Dooley, University of Florida A patient performs the the finger-tapping test with Michael Jaffee, M.D., chair and professor of neurology at the University of Florida. Credit: UF Health A video-processing technique developed at the University of Florida that uses artificial intelligence will help neurologists better track the progression of Parkinson’s...
