by Xia & He Publishing Inc. Credit: Journal of Clinical and Translational Hepatology (2024). DOI: 10.14218/JCTH.2023.00207 Nonalcoholic fatty liver disease (NAFLD), now reclassified as metabolic dysfunction-associated steatotic liver disease (MASLD), and its more severe form, nonalcoholic steatohepatitis (NASH), renamed metabolic dysfunction-associated steatohepatitis (MASH), are increasingly recognized as major contributors to chronic liver disease (CLD) and...
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FDA approves Capvaxive pneumococcal 21-valent conjugate vaccine
by Lori Solomon The U.S. Food and Drug Administration has approved Merck’s Capvaxive pneumococcal 21-valent conjugate vaccine for the prevention of invasive pneumococcal disease and pneumococcal pneumonia in adults. Capvaxive is specifically designed to help protect adults against the serotypes that cause the majority of invasive pneumococcal disease cases, including Streptococcus pneumoniae serotypes 3, 6A,...
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FDA expands pediatric indication for Rinvoq
by Lori Solomon The U.S. Food and Drug Administration has expanded indications for AbbVie’s Rinvoq (upadacitinib) to now include pediatric patients (ages 2 years and older) with polyarticular juvenile idiopathic arthritis (pJIA) and psoriatic arthritis (PsA). Rinvoq is indicated for pediatric patients with an inadequate response or intolerance to one or more tumor necrosis factor...
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Enhancing Medical Billing Through Advanced Data Analytics
Medical billing is a critical factor in the medical industry and involves submitting and following up on claims. These follow-ups are conducted with health insurance companies so medical practitioners can be reimbursed timeously for their services. In theory, this is a simple process. However, it remains complex as there are multiple considerations, like coding accuracy,...
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New Guidance on CGRPs as First-Line Migraine Prevention: How/Will it Change Clinical Practice?
Eve Bender June 20, 2024 A position statement released by the American Headache Society (AHS) earlier this year recommended adding calcitonin gene-related peptide (CGRP)–targeting medications to the list of first-line therapies for migraine prevention. The guidance replaces recommendations published in 2021 that advised clinicians consider CGRP therapy only after patients fail at least two classes...
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Ghrelin Paradox: Unlocking New Avenues in Obesity Management
Ghrelin Paradox: Unlocking New Avenues in Obesity ManagementDimpi Desai, MD; Ashni Dharia, MD DISCLOSURES | June 21, 2024 Despite their best efforts, 80% of people who lose weight regain itand many end up heavier within 5 years. Why? Our bodies fight back, revving up hunger while slowing metabolism after weight loss. In ongoing obesity discussions,...
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Electroconvulsive therapy or ketamine? Clinical factors affect outcomes
by UT Southwestern Medical Center Treatment outcomes of ketamine vs electroconvulsive therapy (ect) stratified by less or more severe baseline depression severity. The least-squares mean from mixed-effects model analyses was plotted for both treatment groups (ECT and ketamine) based on the 16-item Quick Inventory of Depressive Symptomatology Self-Report (QIDS-SR16) baseline depression severity thresholds of moderate...
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Is it time to stop recommending strict salt restriction in people with heart failure? – cardiology
by Wiley Credit: CC0 Public Domain For decades, it’s been thought that people with heart failure should drastically reduce their dietary salt intake, but some studies have suggested that salt restriction could be harmful for these patients. A recent review in the European Journal of Clinical Investigation that assessed all relevant studies published between 2000...
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Research team identifies target protein regulating autoimmune disease lupus
by Pohang University of Science and Technology Schematic of the mechanism of action of ETV5 on TFH cell differentiation. Credit: POSTECHA research team including Professor Yoontae Lee and Jiho Park, a Ph.D. candidate, from the Department of Life Sciences at Pohang University of Science and Technology (POSTECH) has discovered that a particular protein promotes the...
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Sorting therapeutic stem cells by function improves healing after heart attack, lab study shows -cardiology
by Wayne Lewis, University of California, Los Angeles Nanovials containing individual cells (green) and secreted extracellular vesicles (magenta) within their cavities. Credit: Doyeon Koo/UCLASelecting specific cells to be used in an investigational therapy has led to improved recovery of heart function in a new study employing a lab model for myocardial infarction, the medical term...