NEWS RELEASE 22-JUL-2024 Peer-Reviewed PublicationUNIVERSITY OF EASTERN FINLAND Drug repurposing shows promise in the treatment of retinal degenerations, according to a new study by an international team of researchers, published in Nature Communications. A combination treatment incorporating three existing drugs – tamsulosin, metoprolol and bromocriptine – slowed disease progression in pre-clinical retinopathy models. Drug repurposing...
Month: <span>July 2024</span>
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Study identifies new biomarkers of Alzheimer’s disease
JULY 22, 2024 by Ingrid Fadelli , Medical Xpress Study overview. Credit: Nature Human Behaviour (2024). DOI: 10.1038/s41562-024-01924-6Recent advances in the study of proteomes (i.e., the entire range of proteins expressed by human cells and tissues) have opened new opportunities for identifying the biological markers of specific diseases or mental disorders. This could in turn...
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Researchers turn the body’s B cells into tiny surveillance machines, antibody factories
JULY 22, 2024 by Leigh Hopper, University of Southern California Genome editing at the constant region of the IgH locus. a, Antibody H chains are encoded by a rearranged variable domain (VH) spliced to a constant region that can be altered by class switch recombination. b, K562 cells were edited with Cas9 RNPs programmed by...
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New nanoparticle delivery method targets sickle cell mutations in bone marrow
JULY 19, 2024 by Johnny Moseman, Johns Hopkins University Discovery and development of BM-homing LNPs. a, Schematic of LNP preparation including covalent lipid species (covalent lipids and crosslinkers). b, Addition of a covalent lipid or crosslinker to the base-4-lipid LNP formulation leads to BM mRNA delivery and genome editing in a great breadth of unique...
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Understanding molecular drivers of lymphedema
JULY 19, 2024 by Olivia Dimmer, Northwestern University Credit: Journal of Clinical Investigation (2024). DOI: 10.1172/JCI176577 Northwestern Medicine scientists have uncovered molecular mechanisms underlying lymphatic valve development, a discovery which could prove useful in treating lymphedema, according to a study published in the Journal of Clinical Investigation. Lymphedema, a chronic condition that causes localized swelling,...
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How Does Cortisol Affect The Body?
By Marzia KhanReviewed by Danielle Ellis, B.Sc. Biological functions of cortisolEffects of cortisol on different systemsCortisol imbalance and health issuesManaging cortisol levelsConclusionReferencesFurther reading Cortisol is commonly known as the body’s stress hormone and has a range of effects on various functions within the body. Image Credit: GoodStudio/Shutterstock.com This glucocorticoid is a steroid hormone that is...
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NAD Benefits: From Healthy Aging to Higher Energy Levels
SCIENCE & TECHNOLOGY NEWS Ever wished there was a magic potion that could boost your energy, help you age gracefully, and boost your cognitive function? While it’s true that the fountain of youth is still undiscovered, NAD comes pretty close. This powerhouse molecule plays a vital role in many bodily functions. Research suggests NAD might...
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From Dr. Oz to heart valves: A tiny device charted a contentious path through the FDA
JULY 15, 2024 by David Hilzenrath, Holly K. Hacker, KFF Health News MitraClip. Credit: Wikimedia Commons Hellerhoff Creative Commons Attribution-Share Alike 3.0 Unported license.In 2013, the FDA approved an implantable device to treat leaky heart valves. Among its inventors was Mehmet Oz, the former television personality and former U.S. Senate candidate widely known as “Dr....
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FDA approves Zoryve for atopic dermatitis
JULY 12, 2024 by Lori Solomon The U.S. Food and Drug Administration has approved Arcutis Biotherapeutics’ Zoryve (roflumilast) cream, 0.15%, for the treatment of mild-to-moderate atopic dermatitis in adult and pediatric patients (ages 6 years and older). Zoryve is a once-daily, steroid-free cream that the company says will be available at the end of July....
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Progress in the management of patients with cholestatic liver disease: Where are we and where are we going?
JULY 12, 2024 by Xia & He Publishing Inc. Graphical abstract. Credit: Journal of Clinical and Translational Hepatology (2024). DOI: 10.14218/JCTH.2023.00519Cholestatic liver diseases (CLDs) are a group of disorders characterized by the impairment of bile formation, secretion, or excretion. This impairment leads to bile acid accumulation in the liver, causing liver biochemical abnormalities and histological...