September 3, 2024 by Johns Hopkins University School of Medicine In a sea of cancer cells (blue), macrophages (green) are close neighbors to metastatic-initiating cancer cells (magenta). Credit: Won Jin Ho, Johns Hopkins Kimmel Cancer CenterIn a study using human breast cancer cells, scientists say they have potentially identified immune system white blood cells that...
September 3, 2024 by Impact Journals LLC FLNB and ACTC1 analysis. (A) mRNA FLNB expression (RT-qPCR) of fibroblasts in quiescence or after 24h of TGF-β-1 stimulation (Mean±SEM, n= 6 for young and old cells); (B) mRNA expression quantified by RT-qPCR after transfection with specific siRNA for FLNB (siFLNB) or with Scramble siRNA (siScramble), in quiescence...
September 3, 2024 by University of Texas at Austin Graphical abstract. Credit: Cell Reports Medicine (2024). DOI: 10.1016/j.xcrm.2024.101668Researchers have discovered an antibody able to neutralize all known variants of SARS-CoV-2, the virus that causes COVID-19, as well as distantly related SARS-like coronaviruses that infect other animals. As part of a new study on hybrid immunity...
September 3, 2024. by Krishna Ramanujan, Cornell University Microcarrier-microbioreactor setup and protocol. Credit: Journal of Translational Medicine (2024). DOI: 10.1186/s12967-024-05373-7A new approach to manufacturing cells that secrete and deliver therapies to specific parts of the body has taken a big step toward one day repairing joints and damage after heart attacks, countering transplant rejection and...
September 3, 2024 by Molly Chiu, Baylor College of Medicine Credit: Cell Stem Cell (2024). DOI: 10.1016/j.stem.2024.08.006Researchers at Baylor College of Medicine, the University of Michigan and collaborating institutions have discovered that inflammation in the gut leaves long-term marks on intestinal stem cells (ISCs) that reduce their ability to heal the intestine, even after inflammation...
September 3, 2024 by CUNY Advanced Science Research Center Cultured p53 null OPC over-expressing PDGF-BB are highly proliferative and tend to aggregate in low-adhesion conditions. Credit: Neoplasia (2024). DOI: 10.1016/j.neo.2024.101042A new study from researchers with the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) sheds light on why certain oligodendrocyte progenitor cells...
September 4, 2024 by Kendall Staton, Lexington Herald-Leader Pancreatic cancer cells (blue) growing as a sphere encased in membranes (red). Credit:National Cancer Institute Researchers at the University of Kentucky are testing the effectiveness of a vaccine that may be able to treat pancreatic cancer. As one of 15 research institutions across the nation taking part...
September 3, 2024 by Ingrid Fadelli , Medical Xpress (A) Study design. (B) UMAP embedding of nuclei assigned to 11 excitatory, 10 inhibitory, and 3 glial types using DNA methylation in 100 kb bins. (C) RNA expression and gene body DNA methylation at non-CG sites (mCH) for cell type marker genes. (D) Correspondence of mRNA,...
September 3, 2024 by Perelman School of Medicine at the University of Pennsylvania Credit: Unsplash/CC0 Public DomainTaking the weight loss medication semaglutide did not increase the risk of depressive symptoms, suicidal thoughts, or suicidal behavior in persons without known major mental health disorders, according to a new study led by researchers from the Perelman School...
September 3, 2024 by Maria Fernanda Ziegler, FAPESP Lung autopsy tissue infected by SARS-CoV-2 with endothelial cells (red), active inflammasome (green) and SARS-CoV-2 RNA (pink), showing that the virus was replicating. Credit: Keyla de SáAccording to an article published in the journal PLOS Pathogens, severe COVID-19 patients can be divided into two distinct groups: those...
