October 1, 2024 by Allen Institute for Brain Science The BRAIN Initiative Cell Atlas Network (BICAN) has launched its first major data release, marking a significant milestone in the ambitious effort to map the whole human brain. The data, accessible through the BICAN Rapid Release Inventory, includes single-cell and single-nucleus transcriptomic and epigenomic profiles from...
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Life-saving spongelike ‘bandage’ developed by researchers rapidly stops hemorrhaging and mitigates risk of infection
Kausik Mukhopadhyay, assistant professor of materials science and engineering at UCF, and Pritha Sarkar, a graduate student in the material science department at UCF, test their spongelike hemostatic bandage known as “SilFoam” on a mannequin. The sponge-like foam quickly acts to stop hemorrhaging. (Photo by Antoine Hart). Credit: Antoine Hart Without proper medical intervention, injuries...
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Cohort study sheds light on why the flu vaccine is less effective in older people
September 30, 2024 by Nicole Silbermann, Helmholtz Association of German Research Centres So-called high-dose flu vaccines are available for older people. The reason: their immune system does not always respond sufficiently well to the standard flu vaccines. Why this is the case and the molecular processes behind it are not yet understood. However, in their...
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Regulating iron overload: Liraglutide’s potential benefits
By Dr. Priyom Bose, Ph.D.Reviewed by Benedette Cuffari, M.Sc. Study: Liraglutide Impacts Iron Homeostasis in a Murine Model of Hereditary Hemochromatosis. Image Credit: Peter Togel / Shutterstock.com A recent Endocrinology study assesses the role of liraglutide in regulating iron metabolism in a mouse model of hereditary hemochromatosis, diet-induced obesity, and glucose intolerance. Treatment options for...
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Unique immune response in lupus paves the way for new treatments
Graphical abstract. Credit: Immunity (2024). DOI: 10.1016/j.immuni.2024.09.004 Immune cells called monocytes produce a key inflammatory protein called interleukin-1 beta (IL-1β) through an unconventional pathway in patients with systemic lupus erythematosus, commonly referred to as lupus, according to a new study by Weill Cornell Medicine investigators. The findings, published in Immunity, could lead to new treatments targeting IL-1β to better manage...
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Breast cancer drug shows potential for rare appendix cancer
As an NCI-designated Comprehensive Cancer Center, Moores Cancer Center at UC San Diego Health is among the top 4% of approximately 1,500 cancer centers in the United States, and one of only 57 Comprehensive Cancer Centers in the nation. Credit: Kyle Dykes, UC San Diego Health Researchers at University of California San Diego School of...
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Researchers uncover genetic link between bipolar disorder type I and epilepsy
Sep 30 2024 A team of researchers from the Chinese Academy of Sciences has uncovered compelling evidence of a genetic link between bipolar disorder type I (BD-I) and epilepsy, potentially revolutionizing our understanding of these complex neuropsychiatric conditions. The study, published in Genomic Psychiatry on September 30, 2024, reveals shared genetic variants and a causal...
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Starving cancer cells: Researchers unveil new function of ganoderic acid
Molecular docking and MD simulation analysis of GAA and standard inhibitors (Cytochalasin B and Phloretin) in complex with GLUT1 in its endo- and exofacial conformations. Credit: Mona Alrasheed Bashir Recently, Prof. Huang Qing’s group from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences studied the new functions of ganoderic acids. They...
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For heavy drinkers, chronic pain associated with alcohol withdrawal could be permanent
Credit: Pharmacological Research (2024). DOI: 10.1016/j.phrs.2024.107462 One of the main physical symptoms of alcohol withdrawal is “allodynia”— increased sensitivity to mechanical stimuli that are normally innocuous, which is a clinical sign of chronic pain. In a new animal study published in Pharmacological Research, Scripps Research scientists show that the duration of this heightened sensitivity depends on the amount of alcohol...
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DRUG MAY BOOST MOTIVATION FOR PEOPLE WITH DEPRESSION
SEPTEMBER 25TH, 2024POSTED BY EMORY UNIVERSITY(Credit: Getty Images) TAGS DEPRESSIONMOTIVATIONUNIVERSITY EMORY UNIVERSITYAn anti-inflammatory drug shows promise in boosting motivation for people with depression, a new study reveals. Motivational impairments are a core component of depression and have long been linked with poor treatment outcomes, diminished quality of life, and heightened suicide risk. Growing evidence suggests...