Autophagy plasticity in astrocytes enhances the removal of dementia-causing substances and the potential for brain function recovery. Astrocytes, non-neuronal cells, are a new target for Alzheimer’s disease (AD) treatment Peer-Reviewed PublicationNational Research Council of Science & Technology The mechanism of astrocytic autophagy plasticity plays a crucial role in AD. When the autophagy-regulating genes (LC3B and...
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AI models help redefine core microbiome for personalized therapies
Credit: Cell (2024). DOI: 10.1016/j.cell.2024.09.019 Researchers at Rutgers University-New Brunswick, along with international collaborators, have introduced a novel method for identifying the crucial set of gut microbes commonly found in humans and essential for health. The researchers, whose study was published in Cell, said the discovery offers innovative opportunities for precision nutrition and personalized therapies aimed at managing chronic diseases associated...
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Immunotherapy boosts survival of advanced Hodgkin lymphoma in clinical trial
Credit: CC0 Public Domain A treatment that rallies the immune system to destroy cancer raised the survival rate for advanced Hodgkin lymphoma patients to a remarkable 92%, suggesting a new standard therapy for the disease. The New England Journal of Medicine published the innovative clinical trial results. Young people are most at risk of getting Hodgkin lymphoma,...
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AI ‘liquid biopsies’ using cell-free DNA, protein biomarkers, could aid early detection of ovarian cancer
News Release 30-Sep-2024 Peer-Reviewed PublicationJohns Hopkins Medicine A blood test that uses artificial intelligence (AI) to detect cancer-related genetic changes and protein biomarkers could help screen women for early signs of ovarian cancer, according to a study by researchers at the Johns Hopkins Kimmel Cancer Center in collaboration with several other institutions in the United...
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Researchers close in on understanding possible cause of Alzheimer’s disease
News Release 30-Sep-2024 Awarded four-year, $3.3M grant from National Institutes of Health Grant and Award AnnouncementCase Western Reserve University Matthias Buck, professor of physiology and biophysics view moreCredit: Case Western Reserve University CLEVELAND—With a four-year, $3.3 million grant from the National Institutes of Health (NIH), researchers from Case Western Reserve University will study whether certain...
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Synthetic THC may calm agitation in Alzheimer’s patients
September 30, 2024 by Carole Tanzer Miller A synthetic form of the active ingredient in cannabis helps reduce agitation in people with Alzheimer’s, new research shows. Synthetic THC (dronabinol) also gave patients’ caregivers a boost, according to findings presented at a meeting of the International Psychogeriatrics Association in Buenos Aires. The findings may provide encouragement...
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Using mammograms to detect heart disease
September 30, 2024 by University of California – San Diego In a new study published Sept. 27 in JACC: Advances, researchers with University of California San Diego School of Medicine have found that mammograms could be used as a predictor of cardiovascular disease in women. The retrospective study reviewed nearly 20,000 anonymized mammograms to measure...
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Thaumatin, a natural sweetener with anti-inflammatory potential
September 30, 2024 by Gisela Olias, Leibniz Institute for Food Systems Biology A new study by the Leibniz Institute for Food Systems Biology at the Technical University of Munich shows for the first time that bitter tasting protein fragments (peptides) are produced in the stomach during the digestion of the natural sweetener thaumatin. In a...
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Multiple surgeries could contribute to cognitive decline in older people
September 27, 2024 by University of Sydney Multiple surgeries could lead to cognitive decline, a University of Sydney study has found, using data from the United Kingdom’s Biobank to analyze half a million patients aged 40 to 69 and followed over 20 years of brain scans, cognitive tests and medical records. Many families have stories...
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New Hypertension Approach Hits Multiple Targets at Low Dose
Medscape Medical News > Conference News > ESC 2024 Sue Hughes September 27, 2024 LONDON — Single-pill combinations that include three or four antihypertensive medications are the way forward for the management of patients with elevated blood pressure, according to experts evaluating the new approach. This multidrug strategy — in which ultralow-dose triple combinations can...