TOPLINE: More than half of the US peer reviewers for four major medical journals received industry payments between 2020-2022, new research shows. Altogether they received more than $64 million in general, non-research payments, with a median payment per physician of $7614. Research payments — including money paid directly to physicians as well as funds related...
Cracking the genomic code
New research from Sharon Torigoe, biology faculty at Lewis & Clark College, is among the first to confirm an important characteristic of an enhancer for the Klf4 gene, which is important for establishing and maintaining naive-state pluripotent stem cells Peer-Reviewed Publication Lewis & Clark College image: Sharon Torigoe, assistant professor of biology at Lewis &...
Large-scale study of children with genetic disorders finds huge benefit of diagnosis
Genetic results from the Deciphering Developmental Disorders (DDD) study have enabled thousands of children with severe developmental disorders to receive better treatment. Peer-Reviewed Publication Wellcome Trust Sanger Institute image: Jaydi today Credit: Photo courtesy of Lisa Hawker Thousands of children with severe developmental disorders have benefited from more targeted treatments and support with genetic insights...
Study finds genetics, not lifestyle, is a major cause of gout
Linking of insulin signaling, the tricarboxylic acid cycle and epigenomic reprogramming cellular pathways with candidate gout-associated genes. Credit: Nature Genetics (2024). DOI: 10.1038/s41588-024-01921-5 A major international study has found that gout is a chronic illness in which genetics is a major cause, rather than the lifestyle choices of the sufferer. Led by University of Otago researchers, the genome-wide...
New study traces Alzheimer’s ‘pathology clock’ at unprecedented cellular resolution
Vulnerable neurons during the early stages of Alzheimer’s disease. Credit: Allen Institute Researchers at the Allen Institute for Brain Science, UW Medicine, and Kaiser Permanente Washington Health Research Institute have created the most detailed picture yet of how Alzheimer’s disease (AD) progresses at the cellular level. Using advanced single-cell genomic technologies and novel machine learning...
Scientists identify key protein in the inflammatory pathway driving fatty liver disease
Graphical abstract. Credit: Immunity (2024). DOI: 10.1016/j.immuni.2024.08.016 Scientists at the Agency for Science, Technology and Research (A*STAR) and the Shanghai Institute of Immunology (SII), along with their international collaborators, have dissected the key signaling mechanism driving inflammation in metabolic dysfunction-associated steatohepatitis (MASH), through which they have also uncovered a promising new protein target to combat the fatty...
Study finds large variation in how girls grow after their first period
September 27, 2024 by University of Gothenburg There is unexpectedly large variation in height growth in girls after their first period. Every second girl grows either more or less in length than the 6–8 centimeters that is considered standard. This has been shown in a study conducted at the University of Gothenburg. The aim of...
Researchers discover what hinders DNA repair in patients with Huntington disease
September 27, 2024 by McMaster University A montage of three images of single striatal neurons transfected with a disease-associated version of huntingtin, the protein that causes Huntington’s disease. Nuclei of untransfected neurons are seen in the background (blue). The neuron in the center (yellow) contains an abnormal intracellular accumulation of huntingtin called an inclusion body...
Two studies find SARS-CoV-2 virus becoming resistant to antiviral drugs used to treat patients
September 27, 2024 by Bob Yirka , Medical Xpress Two studies have found that the virus that causes COVID-19 is becoming resistant to two drugs used to treat patients with infections. In the first study, a combined team from Cornell University and the National Institutes of Health studied the treatment outcomes for patients with compromised...
Study reveals critical role of tRNA modifying enzyme in brain function
September 27, 2024 by Kumamoto University Loss of TRMT10A led to a decrease in the levels of initiator methionine tRNA (tRNAiMet) and a specific glutamine tRNA (tRNAGln). This reduction weakened the initiation of protein synthesis for certain brain genes and made the genetic code for glutamine harder to recognize. As a result, the production of...