Christine Kao/STATIn 2010, the American Heart Association set a decade-long goal to reduce the number of deaths from cardiovascular disease and stroke by 20%. It didn’t happen. Cardiovascular disease is still the number one cause of death in the U.S., and the AHA called it a “disappointment” that the goal wasn’t met.So what went wrong?...
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Protein involved in balancing DNA replication and restarting found
USP50 protein helps balance nuclease and helicase activity during critical processes Peer-Reviewed Publication University of Birmingham A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified in a new study. In a new paper published in Nature Communications, an international team of researchers have found that the...
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The ‘Enormous’ Promise of Focused Ultrasound Now Coming True
After several years of investigating focused ultrasound as a tool in treating Alzheimer’s, the field took a big leap forward this year. Elisa Konofagou, PhD, a biomedical engineer who runs the Ultrasound and Elasticity Imaging Laboratory at Columbia University in the City of New York, published the results of her team’s groundbreaking research in July, demonstrating their noninvasive,...
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Toxic protein may contribute to amyotrophic lateral sclerosis development
Credit: Structure (2024). DOI: 10.1016/j.str.2024.08.002 A toxic version of a certain protein may affect brain, spinal cord and skeletal muscle tissues differently, leading to the complex development and progression of amyotrophic lateral sclerosis (ALS), according to a new study by a team of researchers from Penn State College of Medicine. The study represents a step forward in...
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New clinical model for predicting hip fractures could save lives
Standardized individual 5-year risk of hip fracture according to age at baseline in all women and by different risk factors. Estimates were obtained using flexible parametric survival models with baseline knots placed at the 25th, 50th, and 75th percentile of the uncensored log survival times. Credit: eClinicalMedicine (2024). DOI: 10.1016/j.eclinm.2024.102877 Researchers at Uppsala University have developed a...
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Stem cell therapy reverses type 1 diabetes in world first
Credit: Cell (2024). DOI: 10.1016/j.cell.2024.09.004 A groundbreaking discovery has recently brought hope to millions of people living with type 1 diabetes around the world. In a world first, scientists have successfully used stem cell therapy to reverse type 1 diabetes in a woman. This achievement is being hailed as a major medical breakthrough, as it offers a potential cure...
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Improving the recipe for gene therapy: New treatment for Gaucher disease shows promise
MRI brain scans of mice with Gaucher disease Type III. The scan of a mouse that received the new treatment (left) shows a significant reduction in tissue inflammation (blue) compared to an untreated mouse (right). Credit: Weizmann Institute of Science Gregory and Deborah Macres from California lost their son, Gregory, in 1997, when he was...
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GLP-1 weight-loss meds won’t raise teens’ suicide risk, may even lower it
As with any new drug, parents and doctors may worry that the use of GLP-1 weight-loss meds by children and teens might raise psychiatric risks, including the risk for suicide and suicidal thoughts. But a new study involving more than 54,000 U.S. adolescents found no such link. In fact, obese kids who used the drugs...
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Experts update recommendations for modern approach for systemic sclerosis
Schematic representation of the eight clinical domains covered by the 2023 recommendations. Note that severe prognosis is not represented. The different shades of green boxes labelled A–D represent the Strength of the Recommendation (SoR) as shown in the relative column of table 1. Dotted lines connect same drug or drug class across distinct clinical domains....
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Gene therapy that converts omega-6 to omega-3 fatty acids in the body could combat effects of childhood obesity
Credit: Unsplash/CC0 Public Domain According to the Centers for Disease Control, nearly 20% of children and teens are considered obese. Research shows it can have a dramatic impact on a variety of health conditions, including arthritis, heart conditions and other metabolic problems, and the American Academy of Pediatrics now recommends early and intensive treatment to...