Credit: Unsplash/CC0 Public Domain Groundbreaking research presented at UEG Week 2024 reveals a promising new treatment strategy for type 2 diabetes (T2D) that could significantly reduce or even eliminate the need for insulin therapy. This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of...
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Atopic Dermatitis Control on Biologic Persists Over 3 Years
AMSTERDAM, Netherlands — For patients with atopic dermatitis (AD) who responded to the anti-interleukin (IL)-13 monoclonal antibody lebrikizumab in the pivotal trials, the level of response, including 90% skin clearance, has generally remained unchanged among those followed up for an additional 2 years, according to the latest data from an extension study. At the end...
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Topical JAK Inhibitor Shows Promise for Frontal Fibrosing Alopecia
AMSTERDAM — For frontal fibrosing alopecia (FFA), a disease with no approved therapies, topical delgocitinib attenuated inflammation and generated hair regrowth in women in a controlled phase 2a trial. “This is an exciting avenue for FFA if the data are recapitulated in a larger population. It could be an important new treatment option,” said Maryanne Senna, MD,...
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Hidradenitis Suppurativa Symptoms Eased by Semaglutide-Aided Weight Loss
People with hidradenitis suppurativa (HS) who have overweight or obesity may benefit from adjunctive treatment with the glucagon-like peptide 1 (GLP-1) receptor agonist semaglutide (Ozempic, Wegovy), suggests research presented at the annual meeting of the European Academy of Dermatology and Venereology (EADV). In a small, nonrandomized, observational, retrospective study, semaglutide-aided weight loss was found to...
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Study finds ‘brain endurance training’ boosts cognitive and physical abilities in older adults
Mean (SE) walk, chair-stand, and arm curl exercise performance as a function of group (BET, Exercise, Control), test (pre-, mid-, post-, follow-up) and state (before Stroop, after Stroop). T tests: B = different from BET group, E = different from Exercise group. Credit: Psychology of Sport and Exercise (2024). DOI: 10.1016/j.psychsport.2024.102757 Brain endurance training (BET), a combined cognitive and exercise training...
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Clinical trial finds multidisciplinary approach improves quality of life for movement disorder patients
Credit: Unsplash/CC0 Public Domain A research team has published a randomized clinical trial demonstrating for the first time that a multidisciplinary approach integrating specific physiotherapy and cognitive-behavioral therapy is effective in improving the symptoms and physical aspects of the quality of life of patients with functional movement disorders. The study, published in the journal JAMA Neurology, was led...
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Drugmakers are racing to find the next Wegovy. These obesity trials are ones to watch.
Novo Nordisk’s drug Wegovy, seen here at New City Halstead Pharmacy on April 24, 2024 in Chicago, Illinois, has set a bar for obesity treatment that other companies hope to clear. Scott Olson via Getty Images Within the pharmaceutical industry, a multibillion-dollar race is underway to top Novo Nordisk’s and Eli Lilly’s in-demand obesity drugs. Dozens...
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New Evidence That Plaque Buildup Shouldn’t Be Ignored
Subclinical disease detected on imaging predicts death, report investigators who show that plaque burden found on 3D vascular ultrasound and coronary artery calcium on CT were better predictors of death than traditional risk factors. The work not only highlights the importance of early detection, but it also has clinical implications, said Valentin Fuster, MD, president of the...
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Protein blocking bone development could hold clues for future osteoporosis treatment
Scientists have identified a protein that blocks the activity of bone-forming cells (osteoblasts) by stopping them from maturing during the journey to sites of bone formation. In their paper published in Communications Biology 11 October 2024, a team of researchers led by Dr. Amy Naylor and Professor Roy Bicknell along with their team including Dr. Georgiana Neag...
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Magnetoelectric nanodiscs offer remote brain stimulation without implants or genetic modification
Magnetoelectric nanodiscs for neuromodulation. Credit: Ye Ji Kim et al Novel magnetic nanodiscs could provide a much less invasive way of stimulating parts of the brain, paving the way for stimulation therapies without implants or genetic modification, MIT researchers report. The scientists envision that the tiny discs, which are about 250 nanometers across (about 1/500...