September 26, 2024 by Duke-NUS Medical School Modifying DEAF1 levels can restore muscle function in aging or cachectic muscles by correcting imbalances in muscle stem cells. Credit: Tang Hong-Wen lab (using BioRender)With the global population aging rapidly, sarcopenia, a condition that affects millions of older adults and severely diminishes their quality of life, is emerging...
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Scientists validate new lab test platform for blood biomarkers of Alzheimer’s disease
Credit: Pixabay/CC0 Public Domain University of Pittsburgh scientists have independently validated a new blood test platform that can simultaneously measure more than a hundred biomarkers of Alzheimer’s disease. The platform might improve clinicians’ ability to capture the multifaceted nature of Alzheimer’s pathology and streamline early disease diagnostics. The report is published in Molecular Neurodegeneration. “Alzheimer’s disease should not...
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Novel antibodies against Klebsiella pneumoniae identified
September 26, 2024 by University Medical Center Utrecht Department of Medical Microbiology at UMC Utrecht. Credit: University Medical Center UtrechtResearch at UMC Utrecht has identified 29 novel antibodies against the bacterium Klebsiella pneumoniae, an important cause of drug-resistant infections. Using genetic and functional approaches, the researchers also managed to unravel how these antibodies interact with...
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Scientists develop CAR-T cells to target glioblastoma while sparing healthy tissue
September 26, 2024 by University of Geneva Immunofluorescence staining of a representative human glioblastoma tissue section. In red, the PTPRZ1 markers, and in blue, the cell nuclei. (scale bar: 400 μm). Credit: Denis Migliorini – UNIGE/HUGScientists at UNIGE and HUG have developed CAR-T cells capable of targeting malignant gliomas while preserving healthy tissue. Glioblastoma is...
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Research casts new light on effectiveness of weight loss prevention supplement
September 26, 2024 by University of Glasgow An ingredient that can be added to food to make it more filling may be less effective at preventing weight gain in young people but could help them build more muscle, new research suggests. In a new paper published in eClinicalMedicine, researchers from U.K. universities report on the...
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Unexpected immune response may hold key to long-term cancer remission
September 26, 2024 by Celia Luterbacher, Ecole Polytechnique Federale de Lausanne From left to right: Co-authors Weilin Li, Tom Enbar, Li Tang, and Lucia Bonati. Credit: Alain HerzogResults from a preclinical study in mice led by EPFL, and a collaborative clinical study in patients show that the type 2 immune response—associated with parasitic infection and...
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Phase II results suggest targeted therapy is effective for moderate to severe ulcerative coliti
September 26, 2024 by Cedars-Sinai Medical Center Credit: New England Journal of Medicine (2024). DOI: 10.1056/NEJMoa2314076An international placebo-controlled study led by Cedars-Sinai suggests that a targeted drug therapy that was developed by researchers at Cedars-Sinai is safe and effective at helping people with moderate to severe ulcerative colitis reach clinical remission. Results from the multicenter...
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AI model identifies existing drugs that can be repurposed for treatment of rare diseases
September 25, 2024 by Harvard Medical School There are more than 7,000 rare and undiagnosed diseases globally. Although each condition occurs in a small number of individuals, collectively these diseases exert a staggering human and economic toll because they affect some 300 million people worldwide. Yet, with a mere 5 to 7% of these conditions...
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Promising drug combo targets aggressive bladder cancers
September 25, 2024 by Columbia University Tumors in a section of untreated muscle invasive bladder cancer (left) vs. section treated with Rosiglitazone and Trametinib showing 91% fewer tumors (right). Credit: Columbia UniversityA new study in mice by researchers at the Herbert Irving Comprehensive Cancer Center (HICCC) has identified a promising drug combination for the treatment...
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Semaglutide improves outcomes for obese patients with common skin condition, new study shows
September 25, 2024 by European Academy of Dermatology and Venereology A pioneering study, presented at the European Academy of Dermatology and Venereology (EADV) Congress 2024, demonstrates the significant potential of semaglutide in treating hidradenitis suppurative (HS), a common and chronic skin condition, in people with obesity. This is the first study to explore the use...