September 25, 2024 by University of Pittsburgh Microscopy image showing activated hepatic stellate cells (HSCs), indicated by red staining (left image). Inhibition of CYB1B1 reduces HSC activation (right image), which leads to reduced liver fibrosis. Credit: Tung et al., Science Translational Medicine. 16, eadk8446 (2024)New research from the University of Pittsburgh School of Pharmacy sheds...
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Stem cells map reveals molecular choreography behind individual variation in human development
September 25, 2024 by Johns Hopkins University School of Medicine Cell line variation in the emergence of neural fate from pluripotency (A) Spatial expression on day 6 in SR condition in SA01 and i04 lines.(B) Variation in NANOG and SOX21 expression across PSC lines. (i) Representative images. Scale bar, 100 μm. (ii) Expression levels in...
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Psilocybin Bests SSRI for Major Depression in First Long-Term Comparison
Medscape Medical News > Conference News > ECNP 2024 Kate Johnson September 23, 2024 MILAN — Psilocybin leads to a better overall outcome in the treatment of moderate to severe major depressive disorder (MDD) than the selective serotonin reuptake inhibitor (SSRI) escitalopram, results of the first long-term comparison of the two treatments suggest. “This is...
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Why do obesity drugs seem to treat so many other ailments?
25 September 2024 By Mariana Lenharo The latest injectable obesity drugs could treat many other disorders. Credit: Joe Buglewicz for The Washington Post via Getty There’s a bar in Baltimore, Maryland, that very few people get to enter. It has a cocktail station, beer taps and shelves stacked with spirits. But only scientists or drug-trial...
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Heart failure, atrial fibrillation and coronary heart disease linked to cognitive impairment
Credit: Pixabay/CC0 Public Domain Three common cardiovascular diseases in adults—heart failure, atrial fibrillation and coronary heart disease—are linked to cognitive impairment and increased risk of dementia, according to “Cardiac Contributions to Brain Health,” a new scientific statement from the American Heart Association published today in the journal, Stroke. The scientific statement reviews the latest research examining...
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Mavacamten linked to cardiac biomarker improvements in HFpEF patients
Mavacamten, a drug initially developed to treat hypertrophic cardiomyopathy, has shown signs of reducing heart stress in patients with heart failure with preserved ejection fraction. Heart failure with preserved ejection fraction (HFpEF) affects nearly half of all heart failure patients. It is characterized by the heart’s inability to appropriately fill with blood despite normal pumping strength. Patients...
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Age-related macular degeneration tied to heightened risk for rheumatoid arthritis
Age-related macular degeneration (AMD) is associated with a higher risk for rheumatoid arthritis (RA), according to a study published online Sept. 9 in Scientific Reports. Je Moon Yoon, from Sungkyunkwan University in Seoul, South Korea, and colleagues examined the association between AMD with and without visual disability (VD) and the risk for RA. The analysis included 3.5 million...
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Loneliness increases dementia odds by 31%, study finds
A new study finds persistent loneliness taking a toll on aging brains and significantly raising a person’s odds for dementia. The research tracked self-reports of loneliness and the neurological health of more than 600,000 people worldwide. The study found loneliness was linked to a 31% rise in the likelihood that a person would go on to develop...
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Six-week abortion bans: More than a third of women don’t know they are pregnant by six weeks
More than a third of women don’t know they are pregnant in time to meet the six-week abortion ban active in four U.S. states, a new study finds. About 37% of women who got an abortion in 2021 and 2022 discovered they were pregnant at six weeks or later, according to findings from the sexual and reproductive rights think-tank...
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New drug approach could underpin future weight loss therapies, study indicates
Credit: Pharmacological Research (2024). DOI: 10.1016/j.phrs.2024.107428 Therapies that deliver hydrogen sulfide to cells could one day become the basis of new treatments for obesity and related diseases, new research has concluded. Mounting evidence suggests that hydrogen sulfide plays an important role in the liver. Previous research shows that tiny amounts of hydrogen sulfide in the body regulate...