News Release 24-Sep-2024 Peer-Reviewed PublicationAmerican Chemical Society Spinning artificial spider silk into next-generation medical materialsimage: Scientists are creating artificial spider silk by drawing strands from an array of tiny hollow needles, as shown here, similar to how arachnids do it. Credit: Adapted from ACS Nano 2024, DOI: 10.1021/acsnano.4c08557 It’s almost time to dust off the...
Month: <span>October 2024</span>
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HiTIP-seq profiles epigenomic reprogramming of patient-derived diffuse midline glioma stem cells to epigenetic therapy
News Release 24-Sep-2024 Peer-Reviewed PublicationTsinghua University Press image: Diffuse midline glioma (DMG), H3K27-altered, is a lethal pediatric high-grade tumor, lacking effective treatment options, primarily depending on clinical trials. Epigenetic agent-based immunotherapy has shown promise, but the underlying mechanisms remain unclear. To address the scarcity of tumor samples, researchers utilize patient-derived tumor cells to explore DMG...
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Systemic sclerosis research finds protein TLR8 influences the production of disease-related cytokines
September 23, 2024 by Jan Grabowski, TWINCORE – Zentrum für Experimentelle und Klinische Infektionsforschung TLR8 is expressed in monocytes and cDCs but not pDCs of patients with systemic sclerosis (SSc). Credit: Arthritis & Rheumatology (2024). DOI: 10.1002/art.42964Systemic sclerosis is an autoimmune disease that primarily causes inflammation of the skin, as well as internal organs such...
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Study suggests using neurostimulation therapies on a specific brain circuit could treat PTSD
September 24, 2024 by Brigham and Women’s Hospital Credit: Pixabay/CC0 Public DomainA study led by researchers at Brigham and Women’s Hospital evaluated 193 participants in the Vietnam Head Injury Study with penetrating traumatic brain injury. The team found those with damage connected to their amygdala, the fear center of the brain, were less likely to...
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Combining Semaglutide and Mineralocorticoids May Improve CKD
Medscape Medical News > Conference News > EASD 2024 Nancy A. Melville September 19, 2024 MADRID — The benefits of semaglutide treatment in reducing kidney disease, cardiovascular, and mortality risks in people with type 2 diabetes and chronic kidney disease (CKD) are observed regardless of whether patients are also being treated with mineralocorticoid receptor antagonists...
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Review of performance measures for pain finds those for acute pain treatment lacking
September 24, 2024 by American College of Physicians Credit: CC0 Public DomainA review by the American College of Physicians (ACP) of performance measures designed to evaluate quality of care for those adults suffering from pain found three of six measures relevant to internal medicine physicians to be valid. “Quality Indicators for Pain in Adults: A...
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Fibrosis lacks treatments and methods of reversal: Study pinpoints a promising target for drug therapy
September 23, 2024 by Delthia Ricks , Medical Xpress Model of MERTK mechanisms for regulating TGFβ core fibrotic pathway across various organs. Credit: Science Translational Medicine (2024). DOI: 10.1126/scitranslmed.adj0133Medical science has long been on the hunt for a deeper understanding of the devastating scarring of the body’s organs known as fibrosis, which leads to irrevocable...
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New study shows durability of minimally invasive procedure to combat knee pain
September 23, 2024 by Society of Interventional Radiology Credit: Journal of Vascular and Interventional Radiology (2024). DOI: 10.1016/j.jvir.2024.08.028A new study shows that a minimally invasive treatment for osteoarthritis (OA) in the knees may have a lasting benefit of at least 2 years. Published today in the Journal of Vascular and Interventional Radiology during Pain Awareness...
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Scientists uncover limits of metabolic flexibility in squamous cell skin cancer
September 23, 2024 by Ani Vahradyan, University of California, Los Angeles Microscopy image of a squamous cell carcinoma, stained with glutamine transporter (ASCT2, green) and nuclei (DAPI, blue). This tumor lacks the enzyme LDHA, which normally helps cells process glucose. Credit: William Lowry Lab/UCLAScientists at the Eli and Edythe Broad Center of Regenerative Medicine and...
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Neuroscientists discover complex genetic programs at the root of our movements
September 23, 2024 by University of Geneva The image shows corticospinal neurons in a mouse brain. Credit: Philipp Abe and Advanced Lightsheet Imaging Center Campus BiotechA UNIGE team has discovered the genetic programs that allow motor neurons to retract from the spinal cord. This discovery opens up prospects for combating neurodegeneration. The motor cortex is...