Electronic health record (EHR) documentation seen in primary care does not accurately reflect menopause symptom burden, and many women are not getting the treatment they need, according to a study published online Oct. 1 in Menopause. Mackenzie L. Bevry, Pharm.D., from the Mayo Clinic Health System in Eau Claire, Wisconsin, and colleagues evaluated the extent of menopause symptom...
Post
Epigenetic test could help predict efficacy of immunotherapy in multiple myeloma
Epigenetic characterization of PVR shows the correlation between promoter DNA methylation and expression. Credit: Leukemia (2024). DOI: 10.1038/s41375-024-02419-z Multiple myeloma is a type of blood cancer that appears mainly after the age of 60. Its incidence, therefore, increases with the aging of the population. In this pathology, the bone marrow, the porous structure within the bones that...
Post
Scrutinizing cells for clues to a treatment for muscular dystrophy
Characteristics of Ad-MSCs, BM-MSCs, and XF-iMSCs. Credit: Stem Cell Research & Therapy (2024). DOI: 10.1186/s13287-024-03951-6 A research team led by Associate Professor Hidetoshi Sakurai and Researcher Nana Takenaka-Ninagawa recently demonstrated the superior therapeutic potential of iPS cell-derived mesenchymal stromal cells (iMSCs) compared to primary MSCs as a potential treatment for Ullrich congenital muscular dystrophy. The study is published in Stem...
Post
Study links teen marijuana use to poor academic performance
Generations of parental warnings may not be wrong: A massive study of available data finds that teens who use marijuana have significantly worse outcomes at school. Data from 63 studies involving almost 440,000 youths found “cannabis use during adolescence is probably associated with lower school grades; less likelihood of high school completion, university enrollment and...
Post
Study reveals crucial role of intestinal absorption in preventing dietary-induced fatty liver disease
Researchers found that deficiency of proglucagon-derived peptides can reduce lipid uptake in the intestinal tract. Credit: Dr. Yusuke Seino / Fujita Health University The accumulation of fats in the liver is driven by high-fat diets and obesity, and is becoming an increasingly prevalent global health concern. Characterized by excessive fat accumulation in the liver, this...
Post
New bone conduction implant approved in Europe and US
Sentio bone conduction implant. Credit: Oticon Medical After over two decades of intensive research and development, a new bone conduction implant, the Sentio System, has now been approved for clinical use in both Europe and the United States. This innovative hearing implant originated in a research project at Chalmers University of Technology in collaboration with...
Post
Unveiling immune system responses that induce and maintain autoimmune pancreatitis
Acute exudative pancreatitis on CT scan. Credit: Hellerhoff/Wikipedia Autoimmune pancreatitis (AIP) is a clinical condition characterized by inflammation of the pancreas, caused by the body’s hypersensitivity to its own proteins. AIP is typically accompanied by other organ inflammations such as autoimmune sialadenitis and cholangitis, together categorized as systemic autoimmune disorder, called IgG4-related disease (IgG4-RD). When...
Post
Study shows cancer vaccine blocks tumor progression at early lesion stage
C A cancer vaccine that had little success in clinical trials for patients with advanced tumors could potentially have efficacy if administered earlier in the treatment cycle, according to a study from Vanderbilt researchers. The investigators demonstrated in a mouse model that the cancer vaccine can block tumor progression if administered when the lesions are at an...
Post
Ultra-powered MRI scans show damage to brain’s ‘control center’ is behind long-lasting COVID-19 symptoms
3D projections of the QSM χ maps on the rendered brainstem ROI extracted from the FreeSurfer segmentation for the healthy control group and the COVID group. The COVID group shows increased χ in the brainstem, specifically in the Medulla and Pons (black arrows). Credit: University of Cambridge Damage to the brainstem—the brain’s ‘control center’—is behind...
Post
Scientists use stem cells to recreate a hallmark of Parkinson’s disease in human neurons
Slide showing the development of Lewy bodies. Credit: Armin Bayati from Peter McPherson Lab, The Neuro Lewy bodies are a hallmark of Parkinson’s disease (PD) and other related neurological conditions. Understanding why and how they develop is critical to developing better treatments. A study from The Neuro (Montreal Neurological Institute-Hospital) of McGill University, in collaboration...