Month: <span>October 2024</span>

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AI tools help uncover enzyme mechanisms for lasso peptides
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AI tools help uncover enzyme mechanisms for lasso peptides

September 20, 2024 by Ananya Sen, University of Illinois at Urbana-Champaign Credit: Nature Chemical Biology (2024). DOI: 10.1038/s41589-024-01727-wLasso peptides are natural products made by bacteria. Their unusual lasso shape endows them with remarkable stability, protecting them from extreme conditions. In a new study, published in Nature Chemical Biology, researchers have constructed and tested models for...

Study shows cholesterol enhances exosome-mediated RNA drug delivery
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Study shows cholesterol enhances exosome-mediated RNA drug delivery

September 20, 2024 by Liu Jia, Chinese Academy of Sciences Cholesterol-enriched exosomes merged with the cell surface. Credit: Gan’s labRNA interference (RNAi) technology has gradually become a cutting-edge technology for treating diseases such as genetic disorders and cancer due to its huge potential in gene expression regulation. However, the efficient delivery and safety of short...

Do AI models produce more original ideas than researchers?
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Do AI models produce more original ideas than researchers?

The concepts were judged by reviewers and were not told who or what had created them.By Gemma Conroy Researchers built an artificial intelligence tool that came up with 4000 novel research ideas in a matter of hours. Credit: Malte Mueller/Getty An ideas generator powered by artificial intelligence (AI) came up with more original research ideas...

Cellular sludge around hunger neurons linked to worsening diabetes and obesity
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Cellular sludge around hunger neurons linked to worsening diabetes and obesity

By Pooja Toshniwal PahariaReviewed by Danielle Ellis, B.Sc. Researchers uncover how the buildup of extracellular matrix proteins and sugars prevents insulin from reaching hunger-regulating neurons, leading to disrupted metabolism and increased risk of obesity. Study: Pathogenic hypothalamic extracellular matrix promotes metabolic disease. Image Credit: Love Employee/Shutterstock.comIn a recent study published in Nature, researchers reveal a...

AI is learning to read your emotions, and here’s why that can be a good thing
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AI is learning to read your emotions, and here’s why that can be a good thing

News Release 20-Sep-2024 Peer-Reviewed PublicationTsinghua University Press image: Using both contemporary psychological methods and AI tools can help achieve a clearer path to emotion quantification through artificial intelligence Credit: Feng Liu, East China Normal University Using a fusion of traditional and novel technological methods, researchers are hoping to better quantify emotions to transform the face...

Brain region that controls eye movements found to also play important role in higher cognitive functions
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Brain region that controls eye movements found to also play important role in higher cognitive functions

September 19, 2024 by University of Chicago Credit: CC0 Public Domain The superior colliculus is a midbrain region that is traditionally thought to help animals orient themselves toward important locations in space, like directing their eyes and head toward a bright flash of light. New research from the University of Chicago shows that this part...

Searching for a vaccine against an ancient scourge: Syphilis genetics study points to a potential target
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Searching for a vaccine against an ancient scourge: Syphilis genetics study points to a potential target

September 19, 2024 by University of Connecticut Accumulation of lineage-associated and population-associated missense mutations in select TPA proteins. Credit: The Lancet Microbe (2024). DOI: 10.1016/S2666-5247(24)00087-9Syphilis cases have surged worldwide, leaving public health officials scrounging for ways to stop the spread. Now, a large, collaborative study of syphilis genetics from four continents has found hints of...

Cardiometabolic risk factors in apparently healthy individuals linked to altered coronary microcirculation
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Cardiometabolic risk factors in apparently healthy individuals linked to altered coronary microcirculation

September 19, 2024 by Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.) Credit: CNICA study carried out at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) in Madrid, Spain provides crucial information about the effect of cardiometabolic risk factors and subclinical atherosclerosis on the network of microvessels that irrigate the heart in symptom-free middle-aged individuals. The...

Study confirms fibrosis as a prognostic indicator in the most common breast cancer
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Study confirms fibrosis as a prognostic indicator in the most common breast cancer

September 19, 2024 by The Spanish National Cancer Research Centre Histological slide of cancerous breast tissue. The pink “riverways” are normal connective tissue, and the blue is cancer cells. Credit: Cecil Fox, National Cancer Institute (NIH).The most common breast cancer is HER2-negative, so called because it has low amounts of one of the proteins that...

Antidepressant shows promise for treating brain tumors
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Antidepressant shows promise for treating brain tumors

September 20, 2024 by ETH Zurich Credit: Sohyon Lee and Berend Snijeder / ETH ZurichGlioblastoma is a particularly aggressive brain tumor that at present is incurable. Cancer doctors can extend patients’ life expectancy through operations, radiation, chemotherapy or surgical interventions. Nevertheless, half of patients die within twelve months of diagnosis. Drugs that are effective against...