by Justin Jackson , Medical Xpress Graphical abstract. Credit: Cell (2024). DOI: 10.1016/j.cell.2024.10.042 Institute of Immunobiology-led research has made a significant breakthrough in understanding how the body combats lung cancer. Their study reveals that specific cells, known as fibroblastic reticular cells (FRCs), create environments within tumors that help protect and activate immune cells to fight the cancer...
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Genomic analysis reveals trigger for cytokine storm in lethal COVID-19
by Johns Hopkins University School of Medicine Schematic summary of RAAS pathway. Credit: Proceedings of the National Academy of Sciences (2024). DOI: 10.1073/pnas.2401968121 As part of the COVID-19 International Research Team, researchers at the Johns Hopkins Kimmel Cancer Center, Children’s Hospital of Philadelphia, the University of Pittsburgh and Weill Cornell Medicine discovered a novel cause of cytokine storm—the...
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Brazilian researchers develop 3D artificial skin that is more similar to human skin
by Elton Alisson, FAPESP Photo of the Human Skin Equivalent with Hypodermis (HSEH) developed by researchers at the Brazilian Biosciences National Laboratory. Credit: LNBio Brazilian researchers have used three-dimensional (3D) printing to develop an artificial skin model with properties that are more similar to those of human skin. The structure, called Human Skin Equivalent with Hypodermis...
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Brain plasticity expert Peter Falkai discusses new pathways for treating schizophrenia
Max Planck Institute director Prof. Peter Falkai shares groundbreaking research insights in exclusive Genomic Press InterviewReports and Proceedings Genomic Press image: Peter Falkai, MD, PhD, Munich University Hospital, Germanyview more Credit: Peter Falkai, MD, PhD MUNICH, Germany, 19 November 2024 – In a comprehensive Genomic Press Interview, distinguished psychiatrist Professor Peter Falkai suggests promising new directions...
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Scientists map how ayahuasca affects fear circuits in comprehensive review
New analysis synthesizes decade of research on psychedelic brew’s effects on anxiety and trauma responsesReports and Proceedings Genomic Press image: Plasticity-promoting mechanisms triggered by dimethyltryptamine (DMT) and β-carboline (BC). (A) DMT and BC-induced increase in cortical plasticity are linked to enhanced BDNF levels, although this might result from activation of different receptors. (B) Increased hippocampal...
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Clinical trial demonstrates efficacy and tolerability of new drug for hemophilia patients
by Saarland University Credit: CC0 Public Domain For people with the bleeding disorder hemophilia, life can seem like one continuous state of alertness. If they accidentally cut their finger while chopping vegetables, they have to immediately administer the clotting factor protein that their body either lacks or does not produce enough of. A normal visit to...
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Temporary tattoo printed directly on the scalp offers easy, hair-friendly solution for measuring brainwaves
by Cell Press EEG setup with e-tattoo electrodes. Credit: Nanshu Lu For the first time, scientists have invented a liquid ink that doctors can print onto a patient’s scalp to measure brain activity. The technology, presented December 2 in the journal Cell Biomaterials, offers a promising alternative to the cumbersome process currently used for monitoring brainwaves and diagnosing neurological...
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Muscle loss could increase dementia risk
Reports and Proceedings Radiological Society of North America image: Schematic diagram of research on how skeletal muscle loss is a risk factor for developing dementia.view more Credit: Radiological Society of North America (RSNA) and Kamyar Moradi, M.D. CHICAGO – Skeletal muscle loss is a risk factor for developing dementia, according to a study being presented today...
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COVID infection and age-related blindness
Peer-Reviewed Publication PNAS Nexus image: A section through the retinal pigment epithelium layer from an infected ACE2-expressing mouse: upper image, bright-field plus SARSCoV-2 N-protein (green) and complement component C3b immunofluorescence (magenta); lower image, C3b immunofluorescence alone. Widespread accumulation of C3b is evident, despite only two small regions of N-protein expression. Scale bars: 50 µm.view more Credit:...
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Immunosuppression study helps understand why some prostate cancer treatments do not work as expected
by Tampere University On the left is a tissue sample from the prostate stained with hematoxylin and eosin. Hematoxylin stains the nuclei blue or purple because it binds to DNA, and eosin stains the cytoplasm and proteins red or pink. This method is used in the diagnosis of prostate cancer. Visium technology (in the centre) allows...